ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2010
Involvement of hippocampal jun-N terminal kinase pathway in the enhancement of learning and memory by nicotine.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- The schizophrenia risk gene Map2k7 regulates responding in a novel contingency-shifting rodent touchscreen gambling task.Disease models & mechanisms · 2022Article
- Systems genetic analysis of nicotine withdrawal deficits in hippocampus-dependent learning.Genes, brain, and behavior · 2021Article
- Cognitive rigidity and BDNF-mediated frontostriatal glutamate neuroadaptations during spontaneous nicotine withdrawal.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- CHN2 Promoter Methylation Change May Be Associated With Methamphetamine Dependence.Shanghai archives of psychiatry · 2017Article
- Acute nicotine disrupts consolidation of contextual fear extinction and alters long-term memory-associated hippocampal kinase activity.Neurobiology of learning and memory · 2017Article
- Zebrafish Get Connected: Investigating Neurotransmission Targets and Alterations in Chemical Toxicity.Toxics · 2016Article
- c-Jun-N-terminal kinase 1 is necessary for nicotine-induced enhancement of contextual fear conditioning.Neuroscience letters · 2016Article
- Nicotinic modulation of hippocampal cell signaling and associated effects on learning and memory.Physiology & behavior · 2016Review
- Withdrawal From Chronic Nicotine Reduces Thyroid Hormone Levels and Levothyroxine Treatment Ameliorates Nicotine Withdrawal-Induced Deficits in Hippocampus-Dependent Learning in C57BL/6J Mice.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2015Article
- Thyroid receptor β involvement in the effects of acute nicotine on hippocampus-dependent memory.Neuropharmacology · 2015Article
- Stronger learning recruits additional cell-signaling cascades: c-Jun-N-terminal kinase 1 (JNK1) is necessary for expression of stronger contextual fear conditioning.Neurobiology of learning and memory · 2015Article
- Low dose nicotine attenuates Aβ neurotoxicity through activation early growth response gene 1 pathway.PloS one · 2015Article
- Substance abuse, memory, and post-traumatic stress disorder.Neurobiology of learning and memory · 2014Review
- Dissociation of tolerance and nicotine withdrawal-associated deficits in contextual fear.Brain research · 2014Article
- Nicotine shifts the temporal activation of hippocampal protein kinase A and extracellular signal-regulated kinase 1/2 to enhance long-term, but not short-term, hippocampus-dependent memory.Neurobiology of learning and memory · 2014Article
- Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning.Neurobiology of learning and memory · 2014Review
- Withdrawal from chronic nicotine and subsequent sensitivity to nicotine challenge on contextual learning.Behavioural brain research · 2013Article
- Nicotinic receptors in the dorsal and ventral hippocampus differentially modulate contextual fear conditioning.Hippocampus · 2012Article
- Gadd45b knockout mice exhibit selective deficits in hippocampus-dependent long-term memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2012Article
- Learning and nicotine interact to increase CREB phosphorylation at the jnk1 promoter in the hippocampus.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Despite intense scrutiny over the past 20 years, the reasons for the high addictive liability of nicotine and extreme rates of relapse in smokers have remained elusive. One factor that contributes to the development and maintenance of nicotine addiction is the ability of nicotine to produce long-lasting modifications of behavior, yet little is known about the mechanisms by which nicotine alters the underlying synaptic plasticity responsible for behavioral changes. This study is the first to explore how nicotine interacts with learning to alter gene transcription, which is a process necessary for long-term memory consolidation. Transcriptional upregulation of hippocampal jun-N terminal kinase 1 (JNK1) mRNA was found in mice that learned contextual fear conditioning (FC) in the presence of nicotine, whereas neither learning alone nor nicotine administration alone exerted an effect. Furthermore, the upregulation of JNK1 was absent in beta2 nicotinic receptor subunit knockout mice, which are mice that do not show enhanced learning by nicotine. Finally, hippocampal JNK activation was increased in mice that were administered nicotine before conditioning, and the inhibition of JNK during consolidation prevented the nicotine-induced enhancement of contextual FC. These data suggest that nicotine and learning interact to alter hippocampal JNK1 gene expression and related signaling processes, thus resulting in strengthened contextual memories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.