ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Arrestin competition influences the kinetics and variability of the single-photon responses of mammalian rod photoreceptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 32 citations in OpenAlex.
- The effects of bicarbonate on the aberrant photon response in murine rod photoreceptors.Biophysical journal · 2026Article
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- Local, nonlinear effects of cGMP and Ca2+ reduce single photon response variability in retinal rods.PloS one · 2019Article
- The Binding Properties and Physiological Functions of Recoverin.Frontiers in molecular neuroscience · 2018Review
- Muscarinic receptor regulates extracellular signal regulated kinase by two modes of arrestin binding.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods.The Journal of general physiology · 2016Article
- Effect of Rhodopsin Phosphorylation on Dark Adaptation in Mouse Rods.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Contributions of protein kinases and β-arrestin to termination of protease-activated receptor 2 signaling.The Journal of general physiology · 2016Article
- Article
- Regulation of mammalian cone phototransduction by recoverin and rhodopsin kinase.The Journal of biological chemistry · 2015Article
- Evaluation of the role of g protein-coupled receptor kinase 3 in desensitization of mouse odorant receptors in a Mammalian cell line and in olfactory sensory neurons.Chemical senses · 2014Article
- Modulation of mouse rod response decay by rhodopsin kinase and recoverin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Origin and control of the dominant time constant of salamander cone photoreceptors.The Journal of general physiology · 2012Article
- The cytoplasmic rhodopsin-protein interface: potential for drug discovery.Current drug targets · 2012Review
- Adaptation of mammalian photoreceptors to background light: putative role for direct modulation of phosphodiesterase.Molecular neurobiology · 2011Review
- The functional cycle of visual arrestins in photoreceptor cells.Progress in retinal and eye research · 2011Review
- Variation in rhodopsin kinase expression alters the dim flash response shut off and the light adaptation in rod photoreceptors.Investigative ophthalmology & visual science · 2011Article
- G-protein betagamma-complex is crucial for efficient signal amplification in vision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Identification of key factors that reduce the variability of the single photon response.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Reliable signal transduction via G-protein-coupled receptors requires proper receptor inactivation. For example, signals originating from single rhodopsin molecules vary little from one to the next, requiring reproducible inactivation of rhodopsin by phosphorylation and arrestin binding. We determined how reduced concentrations of rhodopsin kinase (GRK1) and/or arrestin1 influenced the kinetics and variability of the single-photon responses of mouse rod photoreceptors. These experiments revealed that arrestin, in addition to its role in quenching the activity of rhodopsin, can tune the kinetics of rhodopsin phosphorylation by competing with GRK1. This competition influenced the variability of the active lifetime of rhodopsin. Biasing the competition in favor of GRK1 revealed that rhodopsin remained active through much of the single-photon response under the conditions of our experiments. This long-lasting rhodopsin activity can explain the characteristic time course of single-photon response variability. Indeed, explaining the late time-to-peak of the variance required an active lifetime of rhodopsin approximately twice that of the G-protein transducin. Competition between arrestins and kinases may be a general means of influencing signals mediated by G-protein-coupled receptors, particularly when activation of a few receptors produces signals of functional importance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.