ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Distinct inhibitory neurons exert temporally specific control over activity of a motoneuron receiving concurrent excitation and inhibition.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 44 citations in OpenAlex.
- Motor priming is associated with widespread recruitment into neural ensembles and more rapid ensemble transitions.iScience · 2026Article
- Multiple changes in connectivity between buccal ganglia mechanoafferents and motor neurons with different functions after learning that food is inedible inLearning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Repeated stimulation of feeding mechanoafferents inLearning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Variable task switching in the feeding network ofJournal of neurophysiology · 2023Article
- Identification of three elevenin receptors and roles of elevenin disulfide bond and residues in receptor activation in Aplysia californica.Scientific reports · 2023Article
- A Single Central Pattern Generator for the Control of a Locomotor Rolling Wave in MolluscResearch (Washington, D.C.) · 2023Article
- Characterization of anFrontiers in pharmacology · 2023Article
- Specific Plasticity Loci and Their Synergism Mediate Operant Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Identification of an allatostatin C signaling system in mollusc Aplysia.Scientific reports · 2022Article
- Synaptic mechanisms for motor variability in a feedforward network.Science advances · 2020Article
- Computational model of the distributed representation of operant reward memory: combinatoric engagement of intrinsic and synaptic plasticity mechanisms.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Multiple Local Synaptic Modifications at Specific Sensorimotor Connections after Learning Are Associated with Behavioral Adaptations That Are Components of a Global Response Change.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- GABA as a Neurotransmitter in Gastropod Molluscs.The Biological bulletin · 2019Review
- Multifaceted Expression of Peptidergic Modulation in the Feeding System of Aplysia.ACS chemical neuroscience · 2018Review
- Discovery of leucokinin-like neuropeptides that modulate a specific parameter of feeding motor programs in the molluscan model,The Journal of biological chemistry · 2017Article
- Use of theJournal of neurophysiology · 2017Review
- Repetition priming of motor activity mediated by a central pattern generator: the importance of extrinsic vs. intrinsic program initiators.Journal of neurophysiology · 2016Article
- Aplysia Locomotion: Network and Behavioral Actions of GdFFD, a D-Amino Acid-Containing Neuropeptide.PloS one · 2016Article
- Specificity of repetition priming: the role of chemical coding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Recent work suggests that concurrent excitation and inhibition originating in central pattern generators (CPGs) may be used to control rhythmic motoneuronal activity. The specific roles that the inhibition plays in such cases are not well understood, however, in part because of the lack of identification of presynaptic inhibitory neurons. Here we demonstrate that, in the Aplysia feeding CPG, inhibitory inputs may be critical for flexible control of the activity of motoneurons in different forms of behavior. The feeding CPG generates ingestive and egestive motor programs, differing in the high and low activity, respectively, of the motoneuron B8 during the retraction phase of the programs. We show that, during retraction, B8 receives concurrent excitation and inhibition that produces a high-conductance state. The inhibition originates in two types of CPG neurons, B4/5 and B70, that are more active in egestion than ingestion and play a role in suppressing B8 activity during egestion. In turn, the activities of both B4/5 and B70 are suppressed by the ingestion-promoting descending interneuron CBI-3 (for cerebral-buccal interneuron 3). Thus, concurrent excitation and inhibition may be an effective means of controlling motoneuronal activity in a behavior-dependent manner. More detailed analyses reveal, furthermore, that B4/5 and B70 exert complementary actions by acting preferentially in the early and late part of retraction, respectively. Thus, the use of multiple neurons to generate inhibitory inputs to motoneurons that receive concurrent excitation and inhibition brings an additional level of flexibility that allows a temporally specific control of motoneuronal activity within a single phase of motor programs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.