ArticleJournal of clinical microbiology2009
Large dissemination of VIM-2-metallo-{beta}-lactamase-producing pseudomonas aeruginosa strains causing health care-associated community-onset infections.
Article in Journal of clinical microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Protracted outbreaks of VIM-producing Pseudomonas aeruginosa in a surgical intensive care unit in France, January 2018 to June 2024.Antimicrobial resistance and infection control · 2025Article
- Rapid Reversal of Carbapenemase-ProducingAntibiotics (Basel, Switzerland) · 2024Article
- Designing a Multiplex PCR for Rapid and Accurate Detection of Metallobetalactamases Resistant Genes fromIranian journal of pathology · 2023Article
- Genetic basis of molecular mechanisms in β-lactam resistant gram-negative bacteria.Microbial pathogenesis · 2021Review
- Antimicrobial Resistance and Molecular Characterization of Gene Cassettes from Class 1 Integrons inMicrobial drug resistance (Larchmont, N.Y.) · 2020Article
- Molecular Epidemiology and Mechanisms of High-Level Resistance to Meropenem and Imipenem inInfection and drug resistance · 2020Article
- Antimicrobial resistance pattern, genetic distribution of ESBL genes, biofilm-forming potential, and virulence potential ofThe Pan African medical journal · 2020Article
- Prevalence of class 1 integron inTropical medicine and health · 2020Article
- PsrA Regulator Connects Cell Physiology and Class 1 Integron Integrase Gene Expression Through the Regulation of lexA Gene Expression in Pseudomonas spp.Current microbiology · 2019Article
- Association of the genes encoding Metallo-β-Lactamase with the presence of integrons among multidrug-resistant clinical isolates ofInfection and drug resistance · 2019Article
- Molecular epidemiology of carbapenem-resistant Pseudomonas aeruginosa in an endemic area: comparison with global data.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Review
- Case Report: Carbapenemase-Producing Enterobacteriaceae in an Asylum Seeker with Multidrug-Resistant Tuberculosis.The American journal of tropical medicine and hygiene · 2018Article
- Dissemination of VIM-2 producing Pseudomonas aeruginosa ST233 at tertiary care hospitals in Egypt.BMC infectious diseases · 2015Article
- Epidemiology of VIM-1-imipenem resistant Pseudomonas aeruginosa in Iran: A systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Review
- Characterization of the core and accessory genomes of Pseudomonas aeruginosa using bioinformatic tools Spine and AGEnt.BMC genomics · 2014Article
- Role of Imipenem-resistant metallo-beta-lactamase positive pseudomonas aeruginosa carriers in nosocomial infections.Journal of natural science, biology, and medicine · 2013Article
- Detection of metallo-beta-lactamase producing Pseudomonas aeruginosa in intensive care units.The Australasian medical journal · 2013Article
- Dissemination of clinical isolates of Klebsiella oxytoca harboring CMY-31, VIM-1, and a New OXY-2-type variant in the community.Antimicrobial agents and chemotherapy · 2011Article
- The accessory genome of Pseudomonas aeruginosa.Microbiology and molecular biology reviews : MMBR · 2010Review
- Bench-to-bedside review: The role of beta-lactamases in antibiotic-resistant Gram-negative infections.Critical care (London, England) · 2010Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During a 3-year period (May 2005 to April 2008), a series of 45 outpatients presented with community-onset urinary tract infections due to carbapenem-resistant Pseudomonas aeruginosa isolates. Forty of them had a history of previous hospitalization or exposure to healthcare facilities, while the remaining five had not been previously admitted to our healthcare facilities or elsewhere within the preceding 12 months. In 18 outpatients, the carbapenem-resistant organisms caused recurrent community-onset urinary tract infections, while in three outpatients the organisms were also implicated in bacteremic episodes. All 45 single-patient P. aeruginosa isolates harbored the bla(VIM-2) metallo-beta-lactamase (MBL) gene in a common class 1 integron structure. They belonged to one predominant pulsed-field gel electrophoresis type and three sporadically detected types; two of the sporadic clonal types were identified among outpatients without previous exposure to healthcare facilities, while the predominant clonal type was also identified to cause infections in hospitalized patients. This is the first study documenting that MBL-producing P. aeruginosa isolates cause community-onset infections that are related or not with exposure to healthcare facilities. Community-onset infections in our patients most likely resulted from the nosocomial acquisition of MBL producers, followed by a prolonged digestive carriage. The high rate of recurrent infections in the community underlies the difficulty of constraining infections caused by such microorganisms in the extrahospital setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.