ArticleClinical and vaccine immunology : CVI2009
Evaluation of the anti-East Asian CagA-specific antibody for CagA phenotyping.
Article in Clinical and vaccine immunology : CVI, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- The validation of the Helicobacter pylori CagA typing by immunohistochemistry: nationwide application in Indonesia.Acta histochemica · 2020Article
- Article
- Rare Helicobacter pylori Virulence Genotypes in Bhutan.Scientific reports · 2016Article
- Diagnostic Methods of Helicobacter pylori Infection for Epidemiological Studies: Critical Importance of Indirect Test Validation.BioMed research international · 2016Review
- Validation of Urine Test for Detection of Helicobacter pylori Infection in Indonesian Population.BioMed research international · 2015Article
- Article
- Different gastric mucosa and CagA status of patients in India and Japan infected with Helicobacter pylori.Digestive diseases and sciences · 2014Article
- Helicobacter pylori infection and gastroduodenal diseases in Vietnam: a cross-sectional, hospital-based study.BMC gastroenterology · 2010Article
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Authors and funding
19 authors at 6 institutions in 3 countries.
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Abstract
The determination of the cagA genotype is generally based on sequencing the variable 3' region of the cagA gene. In a previous study, we successfully generated an anti-East Asian CagA-specific antibody (anti-EAS Ab) immunoreactive only with the East Asian CagA and not with the Western CagA. In a small number of Japanese patients, anti-EAS Ab appeared to be a useful tool for phenotyping CagA immunohistochemically. The present study was conducted to validate the anti-EAS Ab immunohistochemistry method in a larger number of patients from Vietnam and Thailand. A total of 385 Vietnamese and Thais were recruited. Helicobacter pylori status was determined by a combination of three methods, including culture, histology, and immunohistochemistry with anti-H. pylori antibody. The sensitivity, specificity, and accuracy of the anti-EAS Ab immunohistochemistry method for the diagnosis of CagA phenotype were calculated based on the results of the cagA sequencing as the gold standard. The sensitivity, specificity, and accuracy of our immunohistochemistry method were 96.7%, 97.9%, and 97.1%, respectively. Moreover, anti-EAS Ab was not cross-reactive with noninfected gastric mucosa. In conclusion, immunohistochemistry with anti-EAS Ab appears to be a good method for determination of CagA phenotype.
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