ArticlePlant physiology2009
LIN, a novel type of U-box/WD40 protein, controls early infection by rhizobia in legumes.
Article in Plant physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 99 citations in OpenAlex.
- A recently evolved Nodulin recruited by NIN for root hair rhizobial infection in Medicago truncatula.The New phytologist · 2026Article
- Ubiquitination as a multi-layer regulatory network in legume-rhizobium symbiosis.Plant cell reports · 2026Review
- Article
- Enacting partner specificity in legume-rhizobia symbioses.aBIOTECH · 2025Review
- Cellular basis of legume-rhizobium symbiosis.Plant communications · 2024Review
- Signaling in Legume-Rhizobia Symbiosis.International journal of molecular sciences · 2023Review
- Article
- RPG interacts with E3-ligase CERBERUS to mediate rhizobial infection in Lotus japonicus.PLoS genetics · 2023Article
- Genome-wide analysis of the U-box E3 ubiquitin ligase family role in drought tolerance in sesame (Frontiers in plant science · 2023Article
- Roles of a CCR4-NOT complex component GmNOT4-1 in regulating soybean nodulation.Frontiers in plant science · 2023Article
- Identification of QTL associated with resistance to Phytophthora fruit rot in cucumber (Frontiers in plant science · 2023Article
- How Many Faces Does the Plant U-Box E3 Ligase Have?International journal of molecular sciences · 2022Review
- Structure and Development of the Legume-Rhizobial Symbiotic Interface in Infection Threads.Cells · 2021Review
- SPIKE1 Activates the GTPase ROP6 to Guide the Polarized Growth of Infection Threads inThe Plant cell · 2020Article
- A Homeotic Mutation Changes Legume Nodule Ontogeny into Actinorhizal-Type Ontogeny.The Plant cell · 2020Article
- TheFrontiers in plant science · 2020Article
- Celebrating 20 Years of Genetic Discoveries in Legume Nodulation and Symbiotic Nitrogen Fixation.The Plant cell · 2020Review
- Atypical Receptor Kinase RINRK1 Required for Rhizobial Infection But Not Nodule Development inPlant physiology · 2019Article
- A protein complex required for polar growth of rhizobial infection threads.Nature communications · 2019Article
- A Lotus japonicus E3 ligase interacts with the Nod Factor Receptor 5 and positively regulates nodulation.BMC plant biology · 2018Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
The formation of a nitrogen-fixing nodule requires the coordinated development of rhizobial colonization and nodule organogenesis. Based on its mutant phenotype, lumpy infections (lin), LIN functions at an early stage of the rhizobial symbiotic process, required for both infection thread growth in root hair cells and the further development of nodule primordia. We show that spontaneous nodulation activated by the calcium- and calmodulin-dependent protein kinase is independent of LIN; thus, LIN is not necessary for nodule organogenesis. From this, we infer that LIN predominantly functions during rhizobial colonization and that the abortion of this process in lin mutants leads to a suppression of nodule development. Here, we identify the LIN gene in Medicago truncatula and Lotus japonicus, showing that it codes for a predicted E3 ubiquitin ligase containing a highly conserved U-box and WD40 repeat domains. Ubiquitin-mediated protein degradation is a universal mechanism to regulate many biological processes by eliminating rate-limiting enzymes and key components such as transcription factors. We propose that LIN is a regulator of the component(s) of the nodulation factor signal transduction pathway and that its function is required for correct temporal and spatial activity of the target protein(s).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.