ArticleJournal of the Royal Society, Interface2010
Quantitative analysis of the protein corona on FePt nanoparticles formed by transferrin binding.
Article in Journal of the Royal Society, Interface, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooling and Analysis of Published in Vitro Data: A Proof of Concept Study for the Grouping of Nanoparticles.International journal of molecular sciences · 2015Pooled it
- Nanosystems Containing Proteins: From Fundamentals to Applications.Chemistry, an Asian journal · 2026Review
- Structural and conformational rearrangements of human serum albumin, transferrin, and blood plasma induced by carbosilane dendrimer therapeutic delivery system.Scientific reports · 2025Article
- Single-molecule digital sizing of proteins in solution.Nature communications · 2024Article
- Novel monodisperse FePt nanocomposites for T2-weighted magnetic resonance imaging: biomedical theranostics applications.Nanoscale advances · 2022Review
- Influence of the chirality of carbon nanodots on their interaction with proteins and cells.Nature communications · 2021Article
- Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine.Chemical Society reviews · 2021Review
- Synthesis of a High Affinity Complementary Peptide-Polymer Nanoparticle (NP) Pair Using Phage Display.ACS applied bio materials · 2021Article
- Article
- Analysing the nanoparticle-protein corona for potential molecular target identification.Journal of controlled release : official journal of the Controlled Release Society · 2020Review
- Cancer Nano-Immunotherapy from the Injection to the Target: The Role of Protein Corona.International journal of molecular sciences · 2020Review
- Spherical Nucleic Acids with Tailored and Active Protein Coronae.ACS central science · 2019Article
- Engineering Proteins at Interfaces: From Complementary Characterization to Material Surfaces with Designed Functions.Angewandte Chemie (International ed. in English) · 2018Review
- Modular assembly of proteins on nanoparticles.Nature communications · 2018Article
- Size and shape-dependent cytotoxicity profile of gold nanoparticles for biomedical applications.Journal of materials science. Materials in medicine · 2017Article
- The effect of the serum corona on interactions between a single nano-object and a living cell.Scientific reports · 2017Article
- Effect of the Protein Corona on Antibody-Antigen Binding in Nanoparticle Sandwich Immunoassays.Bioconjugate chemistry · 2017Article
- The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles.International journal of molecular sciences · 2017Review
- Protein corona: Opportunities and challenges.The international journal of biochemistry & cell biology · 2016Review
- The impact of nanoparticle protein corona on cytotoxicity, immunotoxicity and target drug delivery.Nanomedicine (London, England) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanoparticles are finding a rapidly expanding range of applications in research and technology, finally entering our daily life in medical, cosmetic or food products. Their ability to invade all regions of an organism including cells and cellular organelles offers new strategies for medical diagnosis and therapy (nanomedicine), but their safe use requires a deep knowledge about their interactions with biological systems at the molecular level. Upon incorporation, nanoparticles are exposed to biological fluids from which they adsorb proteins and other biomolecules to form a 'protein corona'. These nanoparticle-protein interactions are still poorly understood and quantitative studies to characterize them remain scarce. Here we have quantitatively analysed the adsorption of human transferrin onto small (radius approx. 5 nm) polymer-coated FePt nanoparticles by using fluorescence correlation spectroscopy. Transferrin binds to the negatively charged nanoparticles with an affinity of approximately 26 microM in a cooperative fashion and forms a monolayer with a thickness of 7 nm. By using confocal fluorescence microscopy, we have observed that the uptake of FePt nanoparticles by HeLa cells is suppressed by the protein corona compared with the bare nanoparticles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.