ArticleJournal of virology2009
Packaging of host mY RNAs by murine leukemia virus may occur early in Y RNA biogenesis.
Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 44 citations in OpenAlex.
- Ro60 requires Y3 RNA for cell surface exposure and inflammation associated with cardiac manifestations of neonatal lupus.Journal of immunology (Baltimore, Md. : 1950) · 2013Trial
- Y RNAs: Biogenesis, Function and Implications for the Cardiovascular System.Advances in experimental medicine and biology · 2020Review
- Noncoding RNA Surveillance: The Ends Justify the Means.Chemical reviews · 2018Review
- Circulating Y-RNAs in Extracellular Vesicles and Ribonucleoprotein Complexes; Implications for the Immune System.Frontiers in immunology · 2018Review
- Recruitment of 7SL RNA to assembling HIV-1 virus-like particles.Traffic (Copenhagen, Denmark) · 2018Article
- Interactions between HIV-1 Gag and Viral RNA Genome Enhance Virion Assembly.Journal of virology · 2017Article
- Viral lncRNA: A regulatory molecule for controlling virus life cycle.Non-coding RNA research · 2017Review
- The Host RNAs in Retroviral Particles.Viruses · 2016Review
- Analysis of the human immunodeficiency virus-1 RNA packageome.RNA (New York, N.Y.) · 2016Article
- Transcriptomic comparison of Drosophila snRNP biogenesis mutants reveals mutant-specific changes in pre-mRNA processing: implications for spinal muscular atrophy.RNA (New York, N.Y.) · 2016Article
- Review
- Functional roles of non-coding Y RNAs.The international journal of biochemistry & cell biology · 2015Review
- A retrovirus packages nascent host noncoding RNAs from a novel surveillance pathway.Genes & development · 2015Article
- Promiscuous RNA binding ensures effective encapsidation of APOBEC3 proteins by HIV-1.PLoS pathogens · 2015Article
- Determinants of Moloney murine leukemia virus Gag-Pol and genomic RNA proportions.Journal of virology · 2014Article
- Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions.Nucleic acids research · 2014Article
- Nuclear trafficking of retroviral RNAs and Gag proteins during late steps of replication.Viruses · 2013Review
- Non-coding Y RNAs as tethers and gates: Insights from bacteria.RNA biology · 2013Review
- Why YRNAs? About Versatile RNAs and Their Functions.Biomolecules · 2013Article
- NC-mediated nucleolar localization of retroviral gag proteins.Virus research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Moloney murine leukemia virus (MLV) selectively encapsidates host mY1 and mY3 RNAs. These noncoding RNA polymerase III transcripts are normally complexed with the Ro60 and La proteins, which are autoantigens associated with rheumatic disease that function in RNA biogenesis and quality control. Here, MLV replication and mY RNA packaging were analyzed using Ro60 knockout embryonic fibroblasts, which contain only approximately 3% as much mY RNA as wild-type cells. Virus spread at the same rate in wild-type and Ro knockout cells. Surprisingly, MLV virions shed by Ro60 knockout cells continued to package high levels of mY1 and mY3 (about two copies of each) like those from wild-type cells, even though mY RNAs were barely detectable within producer cells. As a result, for MLV produced in Ro60 knockout cells, encapsidation selectivity from among all cell RNAs was even higher for mY RNAs than for the viral genome. Whereas mY RNAs are largely cytoplasmic in wild-type cells, fractionation of knockout cells revealed that the residual mY RNAs were relatively abundant in nuclei, likely reflecting the fact that most mY RNAs were degraded shortly after transcription in the absence of Ro60. Together, these data suggest that these small, labile host RNAs may be recruited at a very early stage of their biogenesis and may indicate an intersection of retroviral assembly and RNA quality control pathways.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.