ReviewScandinavian journal of trauma, resuscitation and emergency medicine2009
Thrombelastography and tromboelastometry in assessing coagulopathy in trauma.
Review in Scandinavian journal of trauma, resuscitation and emergency medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 255 citations in OpenAlex.
- A systematic review on the rotational thrombelastometry (ROTEM®) values for the diagnosis of coagulopathy, prediction and guidance of blood transfusion and prediction of mortality in trauma patients.Scandinavian journal of trauma, resuscitation and emergency medicine · 2016Pooled it
- The acute management of trauma hemorrhage: a systematic review of randomized controlled trials.Critical care (London, England) · 2011Pooled it
- Impact of experimental haemodilution on platelet function, thrombin generation and clot firmness: effects of different coagulation factor concentrates.Blood transfusion = Trasfusione del sangue · 2013Trial
- Trial
- Machine learning based prediction of platelet concentration from ROTEM measurements.Scientific reports · 2026Article
- Blood product supplementation modulates clotting kinetics, mechanics, and fibrin architecture in an in vitro model of trauma-induced coagulopathy.Thrombosis research · 2026Article
- Comparing Rotational Thromboelastometry and Standard Coagulation Assays for Predicting Intraoperative Bleeding in Pediatric Liver Transplantation.Pediatric transplantation · 2026Article
- DYSREGULATED CLOT MECHANICS AND KINETICS IMPACTED BY INJURY SEVERITY, PREDICT MORTALITY AFTER TRAUMA.Shock (Augusta, Ga.) · 2025Article
- Diagnostic options for blunt abdominal trauma.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Review
- Viscoelastic Hemostatic Assays: A Primer on Legacy and New Generation Devices.Journal of clinical medicine · 2022Review
- Early thromboelastography in acute traumatic coagulopathy: an observational study focusing on pre-hospital trauma care.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Review
- Hypothermia Induced Impairment of Platelets: Assessment With Multiplate vs. ROTEM-AnFrontiers in physiology · 2022Article
- Viscoelastic Testing and Coagulopathy of Traumatic Brain Injury.Journal of clinical medicine · 2021Review
- Perioperative Hypothermia-A Narrative Review.International journal of environmental research and public health · 2021Review
- How Can Rotational Thromboelastometry as a Point-of-Care Method Be Useful for the Management of Secondary Thromboprophylaxis in High-Risk Pregnant Patients?Diagnostics (Basel, Switzerland) · 2021Article
- Whole Blood, Fixed Ratio, or Goal-Directed Blood Component Therapy for the Initial Resuscitation of Severely Hemorrhaging Trauma Patients: A Narrative Review.Journal of clinical medicine · 2021Review
- Whole blood for blood loss: hemostatic resuscitation in damage control.Colombia medica (Cali, Colombia) · 2020Review
- Viscoelastic coagulation test for liver transplantation.Anesthesia and pain medicine · 2020Review
- Hypothermia-Associated Coagulopathy: A Comparison of Viscoelastic Monitoring, Platelet Function, and Real Time Live Confocal Microscopy at Low Blood Temperatures, anFrontiers in physiology · 2020Article
- Only minor stem cell mobilization in head and neck irradiated patients treated with hyperbaric oxygen.Diving and hyperbaric medicine · 2019Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Death due to trauma is the leading cause of lost life years worldwide, with haemorrhage being responsible for 30-40% of trauma mortality and accounting for almost 50% of the deaths the initial 24 h. On admission, 25-35% of trauma patients present with coagulopathy, which is associated with a several-fold increase in morbidity and mortality. The recent introduction of haemostatic control resuscitation along with emerging understanding of acute post-traumatic coagulability, are important means to improve therapy and outcome in exsanguinating trauma patients. This change in therapy has emphasized the urgent need for adequate haemostatic assays to monitor traumatic coagulopathy and guide therapy. Based on the cell-based model of haemostasis, there is emerging consensus that plasma-based routine coagulation tests (RCoT), like prothrombin time (PT) and activated partial thromboplastin time (APTT), are inappropriate for monitoring coagulopathy and guide therapy in trauma. The necessity to analyze whole blood to accurately identify relevant coagulopathies, has led to a revival of the interest in viscoelastic haemostatic assays (VHA) such as Thromboelastography (TEG) and Rotation Thromboelastometry (ROTEM). Clinical studies including about 5000 surgical and/or trauma patients have reported on the benefit of using the VHA as compared to plasma-based assays, to identify coagulopathy and guide therapy. This article reviews the basic principles of VHA, the correlation between the VHA whole blood clot formation in accordance with the cell-based model of haemostasis, the current use of VHA-guided therapy in trauma and massive transfusion (haemostatic control resuscitation), limitations of VHA and future perspectives of this assay in trauma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.