ArticleGenetics, selection, evolution : GSE2009
Genetic variation in the pleiotropic association between physical activity and body weight in mice.
Article in Genetics, selection, evolution : GSE, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Biological/Genetic Regulation of Physical Activity Level: Consensus from GenBioPAC.Medicine and science in sports and exercise · 2018Review
- High Fat High Sugar Diet Reduces Voluntary Wheel Running in Mice Independent of Sex Hormone Involvement.Frontiers in physiology · 2017Article
- Epistasis and natural selection shape the mutational architecture of complex traits.Nature communications · 2014Article
- The evolution of phenotypic correlations and "developmental memory".Evolution; international journal of organic evolution · 2014Article
- Article
- Differential gene expression in high- and low-active inbred mice.BioMed research international · 2014Article
- Genetic determinants of voluntary exercise.Trends in genetics : TIG · 2013Review
- Genetic linkages for thyroxine released in response to thyrotropin stimulation in three sets of recombinant inbred mice provide evidence for shared and novel genes controlling thyroid function.Thyroid : official journal of the American Thyroid Association · 2013Article
- Exercise and diet affect quantitative trait loci for body weight and composition traits in an advanced intercross population of mice.Physiological genomics · 2012Article
- Recent developments in statistical methods for detecting genetic loci affecting phenotypic variability.BMC genetics · 2012Article
- Evolution of pleiotropy: epistatic interaction pattern supports a mechanistic model underlying variation in genotype-phenotype map.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2011Article
- Evolution of adaptive phenotypic variation patterns by direct selection for evolvability.Proceedings. Biological sciences · 2011Article
- Exercise, weight loss, and changes in body composition in mice: phenotypic relationships and genetic architecture.Physiological genomics · 2011Article
- A search for quantitative trait loci controlling within-individual variation of physical activity traits in mice.BMC genetics · 2010Article
- Strain screen and haplotype association mapping of wheel running in inbred mouse strains.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
- Driven to be inactive? The genetics of physical activity.Progress in molecular biology and translational science · 2010Review
- Genetic variation for body weight change in mice in response to physical exercise.BMC genetics · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundA sedentary lifestyle is often assumed to lead to increases in body weight and potentially obesity and related diseases but in fact little is known about the genetic association between physical activity and body weight. We tested for such an association between body weight and the distance, duration, and speed voluntarily run by 310 mice from the F2 generation produced from an intercross of two inbred lines that differed dramatically in their physical activity levels.
methodsWe used a conventional interval mapping approach with SNP markers to search for QTLs that affected both body weight and activity traits. We also conducted a genome scan to search for relationship QTLs (relQTLs), or chromosomal regions that affected an activity trait variably depending on the phenotypic value of body weight.
resultsWe uncovered seven quantitative trait loci (QTLs) affecting body weight, but only one co-localized with another QTL previously found for activity traits. We discovered 19 relQTLs that provided evidence for a genetic (pleiotropic) association of physical activity and body weight. The three genotypes at each of these loci typically exhibited a combination of negative, zero, and positive regressions of the activity traits on body weight, the net effect of which was to produce overall independence of body weight from physical activity. We also demonstrated that the relQTLs produced these varying associations through differential epistatic interactions with a number of other epistatic QTLs throughout the genome.
conclusionIt was concluded that individuals with specific combinations of genotypes at the relQTLs and epiQTLs might account for some of the variation typically seen in plots of the association of physical activity with body weight.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.