ArticleBMC genomics2009
Transcriptome analysis of the central nervous system of the mollusc Lymnaea stagnalis.
Article in BMC genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Distinct Proteomic Brain States Underlying Long-Term Memory Formation in Aversive Operant Conditioning.Journal of proteome research · 2025Article
- The genome of the simultaneously hermaphroditic snail Lymnaea stagnalis reveals an evolutionary expansion of FMRFamide-like receptors.Scientific reports · 2024Article
- Yolk proteins of the schistosomiasis vector snail Biomphalaria glabrata revealed by multi-omics analysis.Scientific reports · 2024Article
- Identification and characterization of the kynurenine pathway in the pond snail Lymnaea stagnalis.Scientific reports · 2022Article
- Transcriptome analysis provides genome annotation and expression profiles in the central nervous system of Lymnaea stagnalis at different ages.BMC genomics · 2021Article
- What can we teach Lymnaea and what can Lymnaea teach us?Biological reviews of the Cambridge Philosophical Society · 2021Review
- Ion channel profiling of the Lymnaea stagnalis ganglia via transcriptome analysis.BMC genomics · 2021Article
- Comparative Analysis of Neuropeptides in Homologous Interneurons and Prohormone Annotation in Nudipleuran Sea Slugs.Frontiers in physiology · 2021Article
- Neuropeptide Localization inFrontiers in molecular neuroscience · 2021Review
- The pond snail Lymnaea stagnalis.EvoDevo · 2020Review
- Functional shell matrix proteins tentatively identified by asymmetric snail shell morphology.Scientific reports · 2020Article
- The unlimited potential of the great pond snail,eLife · 2020Article
- Aging and disease-relevant gene products in the neuronal transcriptome of the great pond snail (Lymnaea stagnalis): a potential model of aging, age-related memory loss, and neurodegenerative diseases.Invertebrate neuroscience : IN · 2020Article
- Gap Junction Coding Innexin inFrontiers in synaptic neuroscience · 2020Article
- GABA as a Neurotransmitter in Gastropod Molluscs.The Biological bulletin · 2019Review
- Article
- Dopamine-mediated calcium channel regulation in synaptic suppression in L. stagnalis interneurons.Channels (Austin, Tex.) · 2018Article
- Transcriptome of the Australian Mollusc Dicathais orbita Provides Insights into the Biosynthesis of Indoles and Choline Esters.Marine drugs · 2016Article
- Inverse Relationship between Basal Pacemaker Neuron Activity and Aversive Long-Term Memory Formation inFrontiers in cellular neuroscience · 2016Article
- Molecular insights into land snail neuropeptides through transcriptome and comparative gene analysis.BMC genomics · 2015Article
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16 authors.
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Abstract
backgroundThe freshwater snail Lymnaea stagnalis (L. stagnalis) has served as a successful model for studies in the field of Neuroscience. However, a serious drawback in the molecular analysis of the nervous system of L. stagnalis has been the lack of large-scale genomic or neuronal transcriptome information, thereby limiting the use of this unique model.
resultsIn this study, we report 7,712 distinct EST sequences (median length: 847 nucleotides) of a normalized L. stagnalis central nervous system (CNS) cDNA library, resulting in the largest collection of L. stagnalis neuronal transcriptome data currently available. Approximately 42% of the cDNAs can be translated into more than 100 consecutive amino acids, indicating the high quality of the library. The annotated sequences contribute 12% of the predicted transcriptome size of 20,000. Surprisingly, approximately 37% of the L. stagnalis sequences only have a tBLASTx hit in the EST library of another snail species Aplysia californica (A. californica) even using a low stringency e-value cutoff at 0.01. Using the same cutoff, approximately 67% of the cDNAs have a BLAST hit in the NCBI non-redundant protein and nucleotide sequence databases (nr and nt), suggesting that one third of the sequences may be unique to L. stagnalis. Finally, using the same cutoff (0.01), more than half of the cDNA sequences (54%) do not have a hit in nematode, fruitfly or human genome data, suggesting that the L. stagnalis transcriptome is significantly different from these species as well. The cDNA sequences are enriched in the following gene ontology functional categories: protein binding, hydrolase, transferase, and catalytic enzymes.
conclusionThis study provides novel molecular insights into the transcriptome of an important molluscan model organism. Our findings will contribute to functional analyses in neurobiology, and comparative evolutionary biology. The L. stagnalis CNS EST database is available at http://www.Lymnaea.org/.
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