ArticlePloS one2009
Genetic epidemiology of glioblastoma multiforme: confirmatory and new findings from analyses of human leukocyte antigen alleles and motifs.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis.Journal of the National Cancer Institute · 2012Pooled it
- TERT-CLPTM1L polymorphism rs401681 contributes to cancers risk: evidence from a meta-analysis based on 29 publications.PloS one · 2012Pooled it
- Association between brain cancer immunogenetic profile and in silico immunogenicities of 11 viruses.Scientific reports · 2023Article
- Positive Association Between the Immunogenetic Human Leukocyte Antigen (HLA) Profiles of Multiple Sclerosis and Brain Cancer.Neuroscience insights · 2023Article
- Epidemiology of Brain and Other CNS Tumors.Current neurology and neuroscience reports · 2021Review
- HLA polymorphisms and risk of glioblastoma in Koreans.PloS one · 2021Article
- Sex is an important prognostic factor for glioblastoma but not for nonglioblastoma.Neuro-oncology practice · 2019Article
- Nasal Drug Delivery of Anticancer Drugs for the Treatment of Glioblastoma: Preclinical and Clinical Trials.Molecules (Basel, Switzerland) · 2019Review
- Current Options and Future Directions in Immune Therapy for Glioblastoma.Frontiers in oncology · 2018Review
- Non-additive and epistatic effects of HLA polymorphisms contributing to risk of adult glioma.Journal of neuro-oncology · 2017Article
- Decreased human leukocyte antigen A*02:01 frequency is associated with risk of glioma and existence of human cytomegalovirus: a case-control study in Northern China.Cancer immunology, immunotherapy : CII · 2017Article
- Gene expression profiling by mRNA array reveals different pattern in Chinese glioblastoma patients between Uygur and Han populations.International journal of clinical and experimental medicine · 2015Article
- Differential expression and clinical significance of glioblastoma mRNA expression profiles in Uyghur and Han patients in Xinjiang province.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Host genetics and viral load in primary HIV-1 infection: clear evidence for gene by sex interactions.Human genetics · 2014Article
- A hidden Markov model for haplotype inference for present-absent data of clustered genes using identified haplotypes and haplotype patterns.Frontiers in genetics · 2014Article
- Selected human leukocyte antigen class II polymorphisms and risk of adult glioma.Journal of neuroimmunology · 2011Article
- Human leukocyte antigens and HIV type 1 viral load in early and chronic infection: predominance of evolving relationships.PloS one · 2010Article
- The future role of personalized medicine in the treatment of glioblastoma multiforme.Pharmacogenomics and personalized medicine · 2010Article
- Immunoglobulin genes implicated in glioma risk.OncoimmunologyArticle
- An independently validated nomogram for isocitrate dehydrogenase-wild-type glioblastoma patient survival.Neuro-oncology advancesArticle
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9 authors.
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Abstract
backgroundHuman leukocyte antigen (HLA) class I genes mediate cytotoxic T-lymphocyte responses and natural killer cell function. In a previous study, several HLA-B and HLA-C alleles and haplotypes were positively or negatively associated with the occurrence and prognosis of glioblastoma multiforme (GBM). METHODOLOGY/PRINCIPAL
findingsAs an extension of the Upper Midwest Health Study, we have performed HLA genotyping for 149 GBM patients and 149 healthy control subjects from a non-metropolitan population consisting almost exclusively of European Americans. Conditional logistic regression models did not reproduce the association of HLA-B*07 or the B*07-Cw*07 haplotype with GBM. Nonetheless, HLA-A*32, which has previously been shown to predispose GBM patients to a favorable prognosis, was negatively associated with occurrence of GBM (odds ratio=0.41, p=0.04 by univariate analysis). Other alleles (A*29, A*30, A*31 and A*33) within the A19 serology group to which A*32 belongs showed inconsistent trends. Sequencing-based HLA-A genotyping established that A*3201 was the single A*32 allele underlying the observed association. Additional evaluation of HLA-A promoter and exon 1 sequences did not detect any unexpected single nucleotide polymorphisms that could suggest differential allelic expression. Further analyses restricted to female GBM cases and controls revealed a second association with a specific HLA-B sequence motif corresponding to Bw4-80Ile (odds ratio=2.71, p=0.02). CONCLUSIONS/SIGNIFICANCE: HLA-A allelic product encoded by A*3201 is likely to be functionally important to GBM. The novel, sex-specific association will require further confirmation in other representative study populations.
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