ArticleBritish journal of cancer2009
Koilocytes indicate a role for human papilloma virus in breast cancer.
Article in British journal of cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 88 citations in OpenAlex.
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- Human papilloma virus as causal in breast cancer.Frontiers in oncology · 2026Review
- The viral origins of breast cancer.Infectious agents and cancer · 2024Review
- Tracing human papillomavirus in skin and mucosal squamous cell carcinoma: a histopathological retrospective survey.Dermatology reports · 2024Article
- CINNAMON-GUI: Revolutionizing Pap Smear Analysis with CNN-Based Digital Pathology Image Classification.F1000Research · 2024Article
- Histopathological characteristics and HPV status in cervical biopsy specimens diagnosed as flat condyloma.Iranian journal of microbiology · 2023Article
- A comprehensive analysis of penile cancer in the region with the highest worldwide incidence reveals new insights into the disease.BMC cancer · 2022Article
- Identification of Novel Endogenous Controls for qPCR Normalization in SK-BR-3 Breast Cancer Cell Line.Genes · 2021Article
- Human Papillomavirus in Breast Carcinogenesis: A Passenger, a Cofactor, or a Causal Agent?Biology · 2021Review
- Catching viral breast cancer.Infectious agents and cancer · 2021Review
- Assessment of Human Papillomavirus Infection and Risk Factors in Egyptian Women With Breast Cancer.Breast cancer : basic and clinical research · 2021Article
- Prevalence and Type Distribution of High-Risk Human Papillomavirus (HPV) in Breast Cancer: A Qatar Based Study.Cancers · 2020Article
- Laryngeal squamous cell carcinoma and papilloma associated with Equus caballus papillomavirus 2 in a horse.The Journal of veterinary medical science · 2019Article
- Does Male Circumcision Reduce Women's Risk of Sexually Transmitted Infections, Cervical Cancer, and Associated Conditions?Frontiers in public health · 2019Article
- Oncogenic Viruses and Breast Cancer: Mouse Mammary Tumor Virus (MMTV), Bovine Leukemia Virus (BLV), Human Papilloma Virus (HPV), and Epstein-Barr Virus (EBV).Frontiers in oncology · 2018Review
- Multiple oncogenic viruses are present in human breast tissues before development of virus associated breast cancer.Infectious agents and cancer · 2017Article
- Detection of human papillomavirus-16 DNA in archived clinical samples of breast and lung cancer patients from North Pakistan.Journal of cancer research and clinical oncology · 2016Article
- Conisation as a marker of persistent human papilloma virus infection and risk of breast cancer.British journal of cancer · 2016Article
- Human papillomavirus and breast cancer in Iran: a meta- analysis.Iranian journal of basic medical sciences · 2016Review
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7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh-risk human papilloma viruses (HPVs) are candidates as causal viruses in breast cancer. The scientific challenge is to determine whether HPVs are causal and not merely passengers or parasites. Studies of HPV-related koilocytes in breast cancer offer an opportunity to address this crucial issue. Koilocytes are epithelial cells characterised by perinuclear haloes surrounding condensed nuclei and are commonly present in cervical intraepithelial neoplasia. Koilocytosis is accepted as pathognomonic (characteristic of a particular disease) of HPV infection. The aim of this investigation is to determine whether putative koilocytes in normal and malignant breast tissues are because of HPV infection.
methodsArchival formalin-fixed normal and malignant breast specimens were investigated by histology, in situ PCR with confirmation of the findings by standard PCR and sequencing of the products, plus immunohistochemistry to identify HPV E6 oncoproteins.
resultshuman papilloma virus-associated koilocytes were present in normal breast skin and lobules and in the breast skin and cancer tissue of patients with ductal carcinoma in situ (DCIS) and invasive ductal carcinomas (IDCs).
interpretationAs koilocytes are known to be the precursors of some HPV-associated cervical cancer, it follows that HPVs may be causally associated with breast cancer.
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