ArticleBlood2010
Class prediction models of thrombocytosis using genetic biomarkers.
Article in Blood, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 71 citations in OpenAlex.
- Biliverdin reductase B as a new target in breast cancer.Breast cancer research : BCR · 2025Article
- Small molecule BLVRB redox inhibitor promotes megakaryocytopoiesis and stress thrombopoiesis in vivo.Nature communications · 2025Article
- LA-GEM: imputation of gene expression with incorporation of Local Ancestry.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2024Article
- Age-restricted functional and developmental differences of neonatal platelets.Journal of thrombosis and haemostasis : JTH · 2022Article
- Cytokine pathway variants modulate platelet production: IFNA16 is a thrombocytosis susceptibility locus in humans.Blood advances · 2022Article
- Toward platelet transcriptomics in cancer diagnosis, prognosis and therapy.British journal of cancer · 2022Review
- Platelet Heterogeneity in Myeloproliferative Neoplasms.Arteriosclerosis, thrombosis, and vascular biology · 2021Review
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- Heme degradation enzyme biliverdin IXβ reductase is required for stem cell glutamine metabolism.The Biochemical journal · 2018Article
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- The Role of Platelet Microparticle Associated microRNAs in Cellular Crosstalk.Frontiers in cardiovascular medicine · 2018Article
- Platelet RNA signatures for the detection of cancer.Cancer metastasis reviews · 2017Review
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- Gene-expression analysis of clozapine treatment in whole blood of patients with psychosis.Psychiatric genetics · 2016Article
- BLVRB redox mutation defines heme degradation in a metabolic pathway of enhanced thrombopoiesis in humans.Blood · 2016Article
- Predicting chemical bioavailability using microarray gene expression data and regression modeling: A tale of three explosive compounds.BMC genomics · 2016Article
- A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis.PloS one · 2016Article
- MicroRNAs in platelet function and cardiovascular disease.Nature reviews. Cardiology · 2015Review
- RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics.Cancer cell · 2015Article
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9 authors at 3 institutions in 1 country.
Funding
Abstract
Criteria for distinguishing among etiologies of thrombocytosis are limited in their capacity to delineate clonal (essential thrombocythemia [ET]) from nonclonal (reactive thrombocytosis [RT]) etiologies. We studied platelet transcript profiles of 126 subjects (48 controls, 38 RT, 40 ET [24 contained the JAK2V(617)F mutation]) to identify transcript subsets that segregated phenotypes. Cross-platform consistency was validated using quantitative real-time polymerase chain reaction (RT-PCR). Class prediction algorithms were developed to assign phenotypic class between the thrombocytosis cohorts, and by JAK2 genotype. Sex differences were rare in normal and ET cohorts (< 1% of genes) but were male-skewed for approximately 3% of RT genes. An 11-biomarker gene subset using the microarray data discriminated among the 3 cohorts with 86.3% accuracy, with 93.6% accuracy in 2-way class prediction (ET vs RT). Subsequent quantitative RT-PCR analysis established that these biomarkers were 87.1% accurate in prospective classification of a new cohort. A 4-biomarker gene subset predicted JAK2 wild-type ET in more than 85% patient samples using either microarray or RT-PCR profiling, with lower predictive capacity in JAK2V(617)F mutant ET patients. These results establish that distinct genetic biomarker subsets can predict thrombocytosis class using routine phlebotomy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.