ArticleHearing research2010
Processing of broadband stimuli across A1 layers in young and aged rats.
Article in Hearing research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed.
- Partial maintenance of auditory-based cognitive training benefits in older adults.Neuropsychologia · 2014Trial
- Reversal of age-related neural timing delays with training.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Age-related changes in behavioural and neural variability in a decision-making task.Nature communications · 2026Article
- Aging in the Primary Auditory Cortex.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- Expression of group II mGluRs in the inferior colliculus, medial geniculate body, and auditory cortex increases with age.Neuroscience · 2025Article
- Speech sound discrimination in background noise across the lifespan: a comparative study in Mongolian gerbils and humans.Frontiers in aging neuroscience · 2025Article
- Aging effects on the neural representation and perception of consonant transition cues.Hearing research · 2024Article
- Spectral degradation and carrier sentences increase age-related temporal processing deficits in a cue-specific manner.The Journal of the Acoustical Society of America · 2024Article
- Phytosterols reverse antiretroviral-induced hearing loss, with potential implications for cochlear aging.PLoS biology · 2023Article
- Effects of aging on cortical representations of continuous speech.Journal of neurophysiology · 2023Article
- Age-related upregulation of perineuronal nets on inferior collicular cells that project to the cochlear nucleus.Frontiers in aging neuroscience · 2023Article
- Volume electron microscopy reveals age-related circuit remodeling in the auditory brainstem.Frontiers in cellular neuroscience · 2022Article
- Age-related hearing loss is associated with alterations in temporal envelope processing in different neural generators along the auditory pathway.Frontiers in neurology · 2022Article
- Altered Response Dynamics and Increased Population Correlation to Tonal Stimuli Embedded in Noise in Aging Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Inferior collicular cells that project to the auditory thalamus are increasingly surrounded by perineuronal nets with age.Neurobiology of aging · 2021Article
- Hearing loss and brain plasticity: the hyperactivity phenomenon.Brain structure & function · 2021Review
- Cortical Responses to the Amplitude Envelopes of Sounds Change with Age.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Brain Frequency-Specific Changes in the Spontaneous Neural Activity Are Associated With Cognitive Impairment in Patients With Presbycusis.Frontiers in aging neuroscience · 2021Article
- Objective evidence of temporal processing deficits in older adults.Hearing research · 2020Review
- Exaggerated cortical representation of speech in older listeners: mutual information analysis.Journal of neurophysiology · 2020Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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4 authors.
Funding
Abstract
Presbycusis can be considered a slow age-related peripheral and central deterioration of auditory function which manifests itself as deficits in speech comprehension, especially in noisy environments. The present study examined neural correlates of a simple broadband noise stimulus in primary auditory cortex (A1) of young and aged Fischer-Brown Norway (FBN) rats. Age-related changes in unit responses to broadband noise bursts and spontaneous activity were simultaneously recorded across A1 layers using a single shank, 16-channel electrode. Noise bursts were presented contralateral to the left A1 at 80 dB SPL. Aged A1 units displayed increased spontaneous (29%), peak (24%), and steady state response rates (38%) than did young A1 units. This was true across all A1 layers, although age-related differences were significantly greater for layers I-III (43% vs 18%) than lower layers. There was a significant age-related difference in the depth and duration of post-onset suppression between young and aged upper layer A1 units. The present functional differences across layers were consistent with studies showing greatest losses of gamma-aminobutyric acid (GABA) markers in superficial layers of A1 and with anatomic studies showing highest levels of inhibitory neurons located in superficial cortical layers. The present findings were also consistent with aging studies suggesting loss of functional inhibition in other cortical sensory systems.
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Registered trials
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