ArticleAntiviral research2009
Immunization by influenza virus-like particles protects aged mice against lethal influenza virus challenge.
Article in Antiviral research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Blockage of regulatory T cells augments induction of protective immune responses by influenza virus-like particles in aged mice.Microbes and infection · 2017Article
- Designing Two Individual AcMNPV Polyhedrin-Plus Bac-to-Bac Expression System in order to Express GFP and CPV-VP2 in Insect Cells.Iranian journal of biotechnology · 2017Article
- Newcastle disease virus-vectored West Nile fever vaccine is immunogenic in mammals and poultry.Virology journal · 2016Article
- Enhanced Stability of Inactivated Influenza Vaccine Encapsulated in Dissolving Microneedle Patches.Pharmaceutical research · 2016Article
- Glucan supplementation enhances the immune response against an influenza challenge in mice.Annals of translational medicine · 2015Article
- Use of baculovirus expression system for generation of virus-like particles: successes and challenges.Protein expression and purification · 2013Review
- Analytical technologies for influenza virus-like particle candidate vaccines: challenges and emerging approaches.Virology journal · 2013Review
- Hyper-enhanced production of foreign recombinant protein by fusion with the partial polyhedrin of nucleopolyhedrovirus.PloS one · 2013Article
- Influenza Virus-like Particle Containing Two Different Subtypes of Hemagglutinin Confers Protection in Mice Against Lethal Challenge With A/PR8 (H1N1) and A/HK (H3N2) Viruses.Iranian Red Crescent medical journal · 2013Article
- NS1-truncated live attenuated virus vaccine provides robust protection to aged mice from viral challenge.Journal of virology · 2012Article
- Antigenic subversion: a novel mechanism of host immune evasion by Ebola virus.PLoS pathogens · 2012Article
- Article
- Adjuvants that stimulate TLR3 or NLPR3 pathways enhance the efficiency of influenza virus-like particle vaccines in aged mice.Vaccine · 2011Article
- Defective interfering virus protects elderly mice from influenza.Virology journal · 2011Article
- Successful vaccination strategies that protect aged mice from lethal challenge from influenza virus and heterologous severe acute respiratory syndrome coronavirus.Journal of virology · 2011Article
- Article
- Recombinant respiratory syncytial virus F protein expression is hindered by inefficient nuclear export and mRNA processing.Virus genes · 2010Article
- Co-expression vs. co-infection using baculovirus expression vectors in insect cell culture: Benefits and drawbacks.Biotechnology advancesReview
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Influenza virus-like particles (VLPs) were produced in Sf9 insect cells by co-expressing the matrix protein M1 and the surface glycoproteins hemagglutinin (HA) and neuraminidase (NA) using the recombinant baculovirus expression system. The VLPs were morphologically similar to influenza virions. Both HA and NA proteins were incorporated into VLPs and these proteins retained their functional activities. Further, influenza VLPs but not inactivated influenza viruses (IIV) stimulated secretion of inflammatory cytokines from mouse bone marrow-derived dendritic cells (BMDC). Immunogenicity of influenza VLPs and their protective efficacies against lethal influenza virus challenge were evaluated in young and aged mice. Immunization with influenza VLPs induced strong antibody responses against HA that inhibited hemagglutination by influenza virus, similar to IIV vaccines. Compared to young mice, antibody responses in aged mice immunized with a low dose of either influenza VLPs or IIV vaccines exhibited markedly reduced avidity for HA. However, immunization of aged mice with a high dose of influenza VLPs induced antibody responses with high avidity similar to those in young mice. Furthermore, all vaccinated animals survived a lethal challenge by a mouse-adapted influenza virus (A/PR/8/34), indicating that influenza VLPs are highly efficacious for protection against influenza virus infection in both young and aged mice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.