ReviewCurrent rheumatology reports2009
New insights into synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome.
Review in Current rheumatology reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 84 citations in OpenAlex.
- Comparative analysis of whole spine and sacroiliac joint magnetic resonance SPARCC scores in patients with SAPHO syndrome and ankylosing spondylitis.Frontiers in immunology · 2026Article
- Case report of three cases and literature review: is follicular occlusion triad with peripheral/axial spondyloarthritis involvement an analog of SAPHO syndrome?Frontiers in medicine · 2026Article
- Whole-body MRI in arthritis.Skeletal radiology · 2025Review
- Spinal Involvement in Patients with Chronic Non-Bacterial Osteomyelitis (CNO): An Analysis of Distinctive Imaging Features.Journal of clinical medicine · 2023Article
- Axial Skeleton Bone Marrow Changes in Inflammatory Rheumatologic Disorders.Seminars in musculoskeletal radiology · 2023Article
- A case of synovitis-acne-pustulosis-hyperostosis-osteitis syndrome with right pleural effusion.Respiratory medicine case reports · 2023Article
- Synovitis-acne-pustulosis-hyperostosis-osteitis Syndrome with Bilateral Pleural Effusion.Internal medicine (Tokyo, Japan) · 2022Article
- Destructive spondylodiscitis associated with SAPHO syndrome: A case report and literature review.Surgical neurology international · 2022Article
- SAPHO Syndrome Presenting With Atlo-Epistrophic Synovitis and Left Vocal Cord Paresis: A Challenging Diagnosis.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2022Article
- Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome presenting with a cervical vertebral fracture: A case report.North American Spine Society journal · 2021Article
- SAPHO Syndrome Mimicking Infectious Spondylodiscitis and Bone Metastasis.Case reports in rheumatology · 2021Article
- Integrative Analysis of lncRNA-mRNA Profile Reveals Potential Predictors for SAPHO Syndrome.Frontiers in genetics · 2021Article
- Genome-Wide Association Identifies Risk Pathways for SAPHO Syndrome.Frontiers in cell and developmental biology · 2021Article
- Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis (SAPHO): An Interesting Clinical Syndrome.Cureus · 2020Article
- Article
- F-18 FDG PET/CT in 26 patients with SAPHO syndrome: a new vision of clinical and bone scintigraphy correlation.Journal of orthopaedic surgery and research · 2018Article
- Mandibular Osteitis Leading to the Diagnosis of SAPHO Syndrome.Case reports in radiology · 2018Article
- Mandibular Involvement in Recurrent Multifocal Osteomyelitis Associated with SAPHO Syndrome.Iranian journal of otorhinolaryngology · 2018Article
- Radiologists need to be aware of secondary central venous stenosis in patients with SAPHO syndrome.European radiology · 2017Article
- Case report: remarkable remission of SAPHO syndrome in response to Tripterygium wilfordii hook f treatment.Medicine · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 1987, synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome was proposed as an umbrella term for a group of diseases with similar musculoskeletal manifestations, in particular hyperostosis of anterior chest wall, synovitis, and multifocal aseptic osteomyelitis, observed in association with dermatologic conditions such as palmoplantar pustulosis, severe acne, and hidradenitis suppurativa. Despite recent advances in our understanding of the epidemiologic, pathophysiologic, and immunogenetic mechanisms involved in SAPHO syndrome, etiopathogenesis remains poorly understood. Propionibacterium acnes, the microorganism associated with acne, has been recovered on bone biopsy in some patients, but the possible pathogenetic role of an infectious agent in a genetically predisposed individual, resulting in exaggerated inflammatory response as "reactive osteitis," is a largely unproven hypothesis. The newly available whole-body MRI will assist early diagnosis by detecting multifocal osteitis lesions, some of them asymptomatic, in axial (anterior chest wall, spine, and jaws) and nonaxial sites. Moreover, outcomes are vastly improved by treatment with bisphosphonates and tumor necrosis factor-alpha antagonists.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.