ArticleBMC medical genomics2009
Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation.
Article in BMC medical genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- The 330 risk loci known for systemic lupus erythematosus (SLE): a review.Frontiers in lupus · 2024Article
- Exon Array Biomarkers for the Differential Diagnosis of Schizophrenia and Bipolar Disorder.Molecular neuropsychiatry · 2018Article
- Using global gene expression to discriminate thin melanomas with poor outcomes.Molecular & cellular oncology · 2017Article
- Gene Expression Characterization of HPV Positive Head and Neck Cancer to Predict Response to Chemoradiation.Head and neck pathology · 2015Article
- Overlap of expression quantitative trait loci (eQTL) in human brain and blood.BMC medical genomics · 2014Article
- Allelic imbalance associated with the schizophrenia risk SNP rs1344706 indicates a cis-acting variant in ZNF804A.Schizophrenia research · 2014Article
- Gene expression differences predict treatment outcome of merkel cell carcinoma patients.Journal of skin cancer · 2014Article
- Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction.Molecular psychiatry · 2012Article
- Next generation sequence analysis and computational genomics using graphical pipeline workflows.Genes · 2012Article
- The first decade and beyond of transcriptional profiling in schizophrenia.Neurobiology of disease · 2012Review
- An integrative functional genomics approach for discovering biomarkers in schizophrenia.Briefings in functional genomics · 2011Review
- Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism.Translational psychiatry · 2011Article
- MicroRNA signatures associated with immortalization of EBV-transformed lymphoblastoid cell lines and their clinical traits.Cell proliferation · 2011Article
- Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1.Nature genetics · 2010Article
Corrections and comments
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Authors and funding
16 authors at 9 institutions in 2 countries.
Funding
Abstract
backgroundThe purpose of this study was to examine the effects of glucose reduction stress on lymphoblastic cell line (LCL) gene expression in subjects with schizophrenia compared to non-psychotic relatives.
methodsLCLs were grown under two glucose conditions to measure the effects of glucose reduction stress on exon expression in subjects with schizophrenia compared to unaffected family member controls. A second aim of this project was to identify cis-regulated transcripts associated with diagnosis.
resultsThere were a total of 122 transcripts with significant diagnosis by probeset interaction effects and 328 transcripts with glucose deprivation by probeset interaction probeset effects after corrections for multiple comparisons. There were 8 transcripts with expression significantly affected by the interaction between diagnosis and glucose deprivation and probeset after correction for multiple comparisons. The overall validation rate by qPCR of 13 diagnosis effect genes identified through microarray was 62%, and all genes tested by qPCR showed concordant up- or down-regulation by qPCR and microarray. We assessed brain gene expression of five genes found to be altered by diagnosis and glucose deprivation in LCLs and found a significant decrease in expression of one gene, glutaminase, in the dorsolateral prefrontal cortex (DLPFC). One SNP with previously identified regulation by a 3' UTR SNP was found to influence IRF5 expression in both brain and lymphocytes. The relationship between the 3' UTR rs10954213 genotype and IRF5 expression was significant in LCLs (p = 0.0001), DLPFC (p = 0.007), and anterior cingulate cortex (p = 0.002).
conclusionExperimental manipulation of cells lines from subjects with schizophrenia may be a useful approach to explore stress related gene expression alterations in schizophrenia and to identify SNP variants associated with gene expression.
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