ArticlePloS one2009
Interleukin-10 overexpression promotes Fas-ligand-dependent chronic macrophage-mediated demyelinating polyneuropathy.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Review
- Animal models of immune-mediated demyelinating polyneuropathies.Autoimmunity · 2024Review
- Cytokine Gene Polymorphisms in Patients with Chronic Inflammatory Demyelinating Polyneuropathy.Cells · 2023Article
- Deciphering immune mechanisms in chronic inflammatory demyelinating polyneuropathies.JCI insight · 2020Review
- Anti-Inflammatory Effects of Diospyrin on Lipopolysaccharide-Induced Inflammation Using RAW 264.7 Mouse Macrophages.Biomedicines · 2020Article
- FasL on decidual macrophages mediates trophoblast apoptosis: A potential cause of recurrent miscarriage.International journal of molecular medicine · 2019Article
- Novel pathomechanisms in inflammatory neuropathies.Journal of neuroinflammation · 2017Review
- Peripheral Neuropathy and Hindlimb Paralysis in a Mouse Model of Adipocyte-Specific Knockout of Lkb1.EBioMedicine · 2017Article
- Anti-inflammatory effects of oroxylin A on RAW 264.7 mouse macrophages induced with polyinosinic-polycytidylic acid.Experimental and therapeutic medicine · 2016Article
- Reducing neuroinflammation by delivery of IL-10 encoding lentivirus from multiple-channel bridges.Bioengineering & translational medicine · 2016Article
- Anti-Inflammatory Effect of Wogonin on RAW 264.7 Mouse Macrophages Induced with Polyinosinic-Polycytidylic Acid.Molecules (Basel, Switzerland) · 2015Article
- Molecules involved in the crosstalk between immune- and peripheral nerve Schwann cells.Journal of clinical immunology · 2014Review
- Article
- Animal models of autoimmune neuropathy.ILAR journal · 2014Review
- Immunomodulatory effects of Liriope platyphylla water extract on lipopolysaccharide-activated mouse macrophage.Nutrients · 2012Article
- Carriers of the fragile X mental retardation 1 (FMR1) premutation allele present with increased levels of cytokine IL-10.Journal of neuroinflammation · 2012Article
- Decidual macrophages are significantly increased in spontaneous miscarriages and over-express FasL: a potential role for macrophages in trophoblast apoptosis.International journal of molecular sciences · 2012Article
- Systemic reduction of interleukin-4 or interleukin-10 fails to reduce the frequency or severity of experimental cytomegalovirus retinitis in mice with retrovirus-induced immunosuppression.Ophthalmology and eye diseases · 2012Article
- Opposing roles for membrane bound and soluble Fas ligand in glaucoma-associated retinal ganglion cell death.PloS one · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDemyelinating polyneuropathy is a debilitating, poorly understood disease that can exist in acute (Guillain-Barré syndrome) or chronic forms. Interleukin-10 (IL-10), although traditionally considered an anti-inflammatory cytokine, has also been implicated in promoting abnormal angiogenesis in the eye and in the pathobiology of autoimmune diseases such as lupus and encephalomyelitis. PRINCIPAL
findingsOverexpression of IL-10 in a transgenic mouse model leads to macrophage-mediated demyelinating polyneuropathy. IL-10 upregulates ICAM-1 within neural tissues, promoting massive macrophage influx, inflammation-induced demyelination, and subsequent loss of neural tissue resulting in muscle weakness and paralysis. The primary insult is to perineural myelin followed by secondary axonal loss. Infiltrating macrophages within the peripheral nerves demonstrate a highly pro-inflammatory signature. Macrophages are central players in the pathophysiology, as in vivo depletion of macrophages using clodronate liposomes reverses the phenotype, including progressive nerve loss and paralysis. Macrophage-mediate demyelination is dependent on Fas-ligand (FasL)-mediated Schwann cell death. SIGNIFICANCE: These findings mimic the human disease chronic idiopathic demyelinating polyneuropathy (CIDP) and may also promote further understanding of the pathobiology of related conditions such as acute idiopathic demyelinating polyneuropathy (AIDP) or Guillain-Barré syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.