ArticleJournal of hypertension2010
Genotype-phenotype analysis of angiotensinogen polymorphisms and essential hypertension: the importance of haplotypes.
Article in Journal of hypertension, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Multivariate meta-analysis of the association of G-protein beta 3 gene (GNB3) haplotypes with cardiovascular phenotypes.Molecular biology reports · 2014Pooled it
- Blood pressure loci identified with a gene-centric array.American journal of human genetics · 2011Pooled it
- Article
- Effect of Dietary Salt Excess on DNA Methylation and Transcriptional Regulation of Human Angiotensinogen Gene Expression.American journal of hypertension · 2026Article
- Biomarkers for Predicting Blood Pressure Response to Renal Denervation.Current hypertension reports · 2025Review
- Analysis of the combined effect of rs699 and rs5051 on angiotensinogen expression and hypertension.Chronic diseases and translational medicine · 2024Article
- Genetic Variations inJournal of clinical medicine · 2023Article
- Haplotypic variants of COVID-19 related genes are associated with blood pressure and metabolites levels.Journal of medical virology · 2023Article
- A polymorphism in intron I of the human angiotensinogen gene (The Journal of biological chemistry · 2019Article
- Genetics of Human Primary Hypertension: Focus on Hormonal Mechanisms.Endocrine reviews · 2019Review
- Natural selection and local adaptation of blood pressure regulation and their perspectives on precision medicine in hypertension.Hereditas · 2019Review
- Striatin Gene Polymorphic Variants Are Associated With Salt Sensitive Blood Pressure in Normotensives and Hypertensives.American journal of hypertension · 2017Article
- Article
- Association of angiotensinogen gene SNPs and haplotypes with risk of hypertension in eastern Indian population.Clinical hypertension · 2017Article
- Quantification of intact plasma AGT consisting of oxidized and reduced conformations using a modified ELISA.American journal of physiology. Renal physiology · 2016Article
- Dexamethasone promotes hypertension by allele-specific regulation of the human angiotensinogen gene.The Journal of biological chemistry · 2015Article
- The renin angiotensin aldosterone system and insulin resistance in humans.Current hypertension reports · 2013Review
- Nonmodulation as the mechanism for salt sensitivity of blood pressure in individuals with hypertension and type 2 diabetes mellitus.The Journal of clinical endocrinology and metabolism · 2012Article
- Revising the M235T polymorphism position for the AGT gene and reporting a modifying variant in the Brazilian population with potential cardiac and neural impact.Journal of molecular neuroscience : MN · 2012Article
- Hypercontrols in genotype-phenotype analysis reveal ancestral haplotypes associated with essential hypertension.Hypertension (Dallas, Tex. : 1979) · 2012Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesTo better understand the relationship between angiotensinogen (AGT) genetic variation and essential hypertension, AGT genotypes and haplotypes were tested for association with hypertensive endophenotypes and essential hypertension.
methodsTwo hundred and fifty-six Hypertensive Pathotype (HyperPATH)/Specialized Center of Research (SCOR) cases and 126 controls were genotyped for 24 single-nucleotide polymorphisms (SNPs) in the AGT gene. SNPs and AGT haplotypes were tested for association with plasma AGT, renal plasma flow (RPF), and essential hypertension.
resultsNew associations between essential hypertension, plasma AGT, and RPF are reported for alleles -1178G, 6066A, 6152A, 6233C, and 12822C. The maximum odds ratio for association of hypertension and AGT genetic variation was 2.3 [95% confidence interval (CI) 1.5-3.8; P < 0.0003] for allele 6233C. Previous associations for -1074T, -532T, -217A, -6A, and 4072C are confirmed (P < 0.05). Sodium depletion enhances associations between AGT SNPs and plasma AGT. Most individually associated SNPs, including -6A and 4072C, are found on a common complete AGT haplotype, H4 (frequency = 0.09). Individuals with haplotype H4 have significantly higher plasma AGT and reduced RPF (P < 0.003 and P < 0.0002, respectively). Other common haplotypes are not associated with increased plasma AGT levels in this data set despite the presence of the -6A and 4072C alleles, suggesting that AGT haplotype H4 is more predictive of elevated plasma AGT than is -6A or 4072C.
conclusionThis study demonstrates the importance of analyzing haplotypes in addition to single genotypes in association studies. By demonstrating the dependence of AGT associations on sodium depletion status, it helps to explain previous conflicting association results.
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