ArticleJournal of cardiovascular pharmacology2009
Nitric oxide-mediated dilation of arterioles to intraluminal administration of aldosterone.
Article in Journal of cardiovascular pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- SGK1 inhibition exerts atheroprotective effects in vascular endothelial cells.Biochemistry and biophysics reports · 2026Article
- GPER and EGFR cross-talk highlight aldosterone- and MR antagonist-induced NO production in cultured endothelial cells.Frontiers in pharmacology · 2026Article
- Age at natural menopause and development of chronic diseases in the female population of Kharameh, Iran: A historical cohort study.Health science reports · 2024Article
- Hyperglycemia Potentiates Prothrombotic Effect of Aldosterone in a Rat Arterial Thrombosis Model.Cells · 2021Article
- Prenatal hypoxia affected endothelium-dependent vasodilation in mesenteric arteries of aged offspring via increased oxidative stress.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- The potential role of testosterone in hypertension and target organ damage in hypertensive postmenopausal women.Clinical interventions in aging · 2019Article
- Role of Aldosterone and Mineralocorticoid Receptor in Cardiovascular Aging.Frontiers in endocrinology · 2019Review
- Endothelial mineralocorticoid receptor ablation does not alter blood pressure, kidney function or renal vessel contractility.PloS one · 2018Article
- Hormonal therapy with estradiol and drospirenone improves endothelium-dependent vasodilation in the coronary bed of ovariectomized spontaneously hypertensive rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016Article
- Mineralocorticoid Receptors in the Pathophysiology of Vascular Inflammation and Atherosclerosis.Frontiers in endocrinology · 2015Review
- Interfering with mineralocorticoid receptor activation: the past, present, and future.F1000prime reports · 2014Review
- Direct contribution of vascular mineralocorticoid receptors to blood pressure regulation.Clinical and experimental pharmacology & physiology · 2013Review
- Aldosterone affects blood flow and vascular tone regulated by endothelium-derived NO: therapeutic implications.British journal of pharmacology · 2013Review
- TRAIL death receptor 4 signaling via lysosome fusion and membrane raft clustering in coronary arterial endothelial cells: evidence from ASM knockout mice.Journal of molecular medicine (Berlin, Germany) · 2013Article
- Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy.The Journal of clinical investigation · 2012Article
- Minireview: G protein-coupled estrogen receptor-1, GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology.Endocrinology · 2012Review
- Mineralocorticoid receptors in vascular function and disease.Molecular and cellular endocrinology · 2012Review
- Aldosterone stimulates superoxide production in macula densa cells.American journal of physiology. Renal physiology · 2011Article
- Impaired flow-induced dilation of coronary arterioles of dogs fed a low-salt diet: roles of ANG II, PKC, and NAD(P)H oxidase.American journal of physiology. Heart and circulatory physiology · 2010Article
- Nitric oxide release follows endothelial nanomechanics and not vice versa.Pflugers Archiv : European journal of physiology · 2010Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
The nature of the rapid action of aldosterone on blood vessels, whether endothelium-dependent dilation or smooth muscle-dependent constriction is predominant, is still in dispute. In this study, we administered aldosterone intraluminally or extraluminally to isolated mesenteric and cerebral arterioles of male Wistar rats. Extraluminal administration of aldosterone (10(-11) or 10(-7) M) elicited a transient vasodilatation. The peak response appeared at approximately 5 minutes. In contrast, intraluminal administration of aldosterone elicited a greater and sustained dilation. When aldosterone (10(-12)-10(-7) M) was administered extraluminally in a cumulative manner, dose-dependent vasodilator responses were elicited, except a reduced dilation was observed to 10(-7) M aldosterone. The dilations were significantly inhibited by spironolactone (10(-7) M), a mineralocorticoid receptor antagonist or Nomega-nitro-l-arginine methyl ester (3 x 10(-4) M), a NO synthesis inhibitor. In endothelium-denuded vessels, extraluminal aldosterone induced a dose-dependent vasoconstrictor response. Scavenging superoxide with Tempol (10(-4) M) sustained the extraluminal aldosterone (10(-11) or 10(-7) M)-induced dilation, whereas inhibition of NO synthesis or removal of the endothelium abolished intraluminal aldosterone-induced dilation. Dilation to 10(-7) M aldosterone was significantly enhanced after inhibition of NAD(P)H-oxidase with apocynin (10(-5) M). Furthermore, in the presence of endothelial dysfunction, induced by chronic inhibition of NO synthesis, intraluminal administration of aldosterone failed to dilate the arterioles. We conclude that in physiological conditions, acute elevation of aldosterone will evoke mainly an endothelium-dependent NO-mediated dilation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.