Evidence map›Paper›PMID 19770482›Full record

ReviewToxicological sciences : an official journal of the Society of Toxicology2010

Approaches for assessing risks to sensitive populations: lessons learned from evaluating risks in the pediatric population.

Ronald N Hines, Dana Sargent, Herman Autrup, Linda S Birnbaum, Robert L Brent, Nancy G Doerrer, Elaine A Cohen Hubal, Daland R Juberg, Christian Laurent, Robert Luebke and 3 more

Abstract readReview
In one paragraph

Review in Toxicological sciences : an official journal of the Society of Toxicology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Age-Dependent Changes in Cytochrome P450 Abundance and Composition in Human Liver.Drug metabolism and disposition: the biological fate of chemicals · 2024
    Article
  5. Review
  6. Article
  7. Children's Environmental Health: A Systems Approach for Anticipating Impacts from Chemicals.International journal of environmental research and public health · 2020
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. In vitro to in vivo extrapolation for high throughput prioritization and decision making.Toxicology in vitro : an international journal published in association with BIBRA · 2018
    Review
  15. A Review of the Field on Children's Exposure to Environmental Contaminants: A Risk Assessment Approach.International journal of environmental research and public health · 2017
    Review
  16. Article
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ronald N HinesMedical College of Wisconsin, Department of Pediatrics, Children's Research Institute, Children's Hospital and Health Systems, Milwaukee, Wisconsin 53226-4801, USA.
Dana Sargent
Herman Autrup
Linda S Birnbaum
Robert L Brent
Nancy G Doerrer
Elaine A Cohen Hubal
Daland R Juberg
Christian Laurent
Robert Luebke
Klaus Olejniczak
Christopher J Portier
William Slikker

Funding

Statistical Models In Toxicology And BiochemistryZIAES048002 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI PORTIER, CHRISTOPHER J · 2009 to 2010
$2.9M
Regulation of Drug Metabolizing Enzyme OntogenyR01GM081344 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI MCCARVER, D GAIL · 2008 to 2012
$2.7M
NIGMS NIH HHS R01 GM081344
6 · The paper itself

Abstract

Assessing the risk profiles of potentially sensitive populations requires a "tool chest" of methodological approaches to adequately characterize and evaluate these populations. At present, there is an extensive body of literature on methodologies that apply to the evaluation of the pediatric population. The Health and Environmental Sciences Institute Subcommittee on Risk Assessment of Sensitive Populations evaluated key references in the area of pediatric risk to identify a spectrum of methodological approaches. These approaches are considered in this article for their potential to be extrapolated for the identification and assessment of other sensitive populations. Recommendations as to future research needs and/or alternate methodological considerations are also made.

Indexed as

Models, BiologicalAdolescentAdultAge FactorsBiomarkersChildChild, PreschoolDose-Response Relationship, DrugEnvironmental ExposureEnvironmental MonitoringGenetic Predisposition to DiseaseGovernment RegulationHealth PolicyHumansInfantInfant, NewbornBiomarkers

Identifiers

PMID19770482
PMCPMC3469276

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.