ArticleHypertension (Dallas, Tex. : 1979)2009
Leptin impairs cardiovagal baroreflex function at the level of the solitary tract nucleus.
Article in Hypertension (Dallas, Tex. : 1979), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 74 citations in OpenAlex.
- Leptin and Associated Neural Pathways Underlying Obesity-Induced Hypertension.Comprehensive Physiology · 2025Review
- Temporal and region-specific tau hyperphosphorylation in the medulla and forebrain coincides with development of functional changes in male obese Zucker rats.Journal of neurophysiology · 2024Article
- Bradykinin-mediated estrogen-dependent depressor response by direct activation of female-specific distribution of myelinated Ah-type baroreceptor neurons in rats.CNS neuroscience & therapeutics · 2022Article
- The baroreflex afferent pathway plays a critical role in HActa pharmacologica Sinica · 2021Article
- Article
- Parkinson-like early autonomic dysfunction induced by vagal application of DOPAL in rats.CNS neuroscience & therapeutics · 2021Article
- Anti-Hypertensive Action of Fenofibrate via UCP2 Upregulation Mediated by PPAR Activation in Baroreflex Afferent Pathway.Neuroscience bulletin · 2019Article
- Direct activation of tachykinin receptors within baroreflex afferent pathway and neurocontrol of blood pressure regulation.CNS neuroscience & therapeutics · 2019Article
- Ablation of TRPV1 Elevates Nocturnal Blood Pressure in Western Diet-fed Mice.Current hypertension reviews · 2019Article
- Noninvasive assessment of autonomic function in human neonates born at the extremes of fetal growth spectrum.Physiological reports · 2018Article
- FGF21 ameliorates the neurocontrol of blood pressure in the high fructose-drinking rats.Scientific reports · 2016Article
- Effect of Low Dose Atorvastatin Therapy on Baroreflex Sensitivity in Hypertensives.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2016Article
- Facilitation of breathing by leptin effects in the central nervous system.The Journal of physiology · 2016Review
- Medullary Endocannabinoids Contribute to the Differential Resting Baroreflex Sensitivity in Rats with Altered Brain Renin-Angiotensin System Expression.Frontiers in physiology · 2016Article
- Brain inflammation and hypertension: the chicken or the egg?Journal of neuroinflammation · 2015Review
- Alterations in the Medullary Endocannabinoid System Contribute to Age-related Impairment of Baroreflex Sensitivity.Journal of cardiovascular pharmacology · 2015Article
- Control of respiratory and cardiovascular functions by leptin.Life sciences · 2015Review
- Endogenous leptin contributes to baroreflex suppression within the solitary tract nucleus of aged rats.American journal of physiology. Heart and circulatory physiology · 2014Article
- Acute and chronic systemic CB1 cannabinoid receptor blockade improves blood pressure regulation and metabolic profile in hypertensive (mRen2)27 rats.Physiological reports · 2014Article
- Exercise prevents leptin-induced increase in blood pressure in Sprague-Dawley rats.Journal of physiology and biochemistry · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Circulating leptin is elevated in some forms of obesity-related hypertension, associated with impaired baroreflex function. Leptin receptors are present on vagal afferent fibers and neurons within the solitary tract nucleus, providing an anatomic distribution consistent with baroreflex modulation. Although solitary tract nucleus microinjection of 144 fmol/60 nL of leptin had no significant effect on baroreflex sensitivity for control of the heart rate in urethane/chloralose-anesthetized Sprague-Dawley rats, 500 fmol of leptin impaired baroreflex sensitivity for bradycardia in response to increases in pressure (1.15+/-0.04 versus 0.52+/-0.12 ms/mm Hg; P<0.01). Transgenic ASrAOGEN rats with low brain angiotensinogen have an upregulation of the leptin receptor and p85 alpha mRNA in the dorsal medulla relative to Sprague-Dawley rats. Consistent with these observations, the response to leptin was enhanced in ASrAOGEN rats, because both the 144-fmol (1.46+/-0.08 versus 0.75+/-0.10 ms/mm Hg; P<0.001) and 500-fmol (1.36+/-0.32 versus 0.44+/-0.06 ms/mm Hg; P<0.05) leptin microinjections impaired baroreflex sensitivity. At these doses, leptin microinjection had no effect on resting pressure, heart rate, or the tachycardic response to decreases in pressure in Sprague-Dawley or ASrAOGEN rats. Thus, exogenous leptin at sites within the solitary tract nucleus impairs the baroreflex sensitivity for bradycardia induced by increases in arterial pressure, consistent with a permissive role in mediating increases in arterial pressure. Baroreflex inhibition was enhanced in animals with evidence of increased leptin receptor and relevant signaling pathway mRNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.