ArticleAntimicrobial agents and chemotherapy2009
Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosides.
Article in Antimicrobial agents and chemotherapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Small Molecule Drugs Targeting Viral Polymerases.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Review
- An acyclic phosphonate prodrug of HPMPC is effective against VZV in skin organ culture and mice.Antiviral research · 2022Article
- Introduction of a cyano group at the 2-position of an (RSC medicinal chemistry · 2021Article
- Pressurized DNA state inside herpes capsids-A novel antiviral target.PLoS pathogens · 2020Article
- R430: A potent inhibitor of DNA and RNA viruses.Scientific reports · 2018Article
- Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis.Antiviral research · 2018Article
- TAOK3 phosphorylates the methylenecyclopropane nucleoside MBX 2168 to its monophosphate.Antiviral research · 2015Article
- Antiherpesvirus activities of two novel 4'-thiothymidine derivatives, KAY-2-41 and KAH-39-149, are dependent on viral and cellular thymidine kinases.Antimicrobial agents and chemotherapy · 2014Article
- Retinazone inhibits certain blood-borne human viruses including Ebola virus Zaire.Antiviral chemistry & chemotherapy · 2014Article
- KAY-2-41, a novel nucleoside analogue inhibitor of orthopoxviruses in vitro and in vivo.Antimicrobial agents and chemotherapy · 2014Article
- Synthesis and antiviral activities of methylenecyclopropane analogs with 6-alkoxy and 6-alkylthio substitutions that exhibit broad-spectrum antiviral activity against human herpesviruses.Antimicrobial agents and chemotherapy · 2013Article
- Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.Bioorganic & medicinal chemistry · 2012Article
- Bilirubin: An Endogenous Molecule with Antiviral Activity in vitro.Frontiers in pharmacology · 2012Article
- Cyclopropavir inhibits the normal function of the human cytomegalovirus UL97 kinase.Antimicrobial agents and chemotherapy · 2011Article
- CMX001 potentiates the efficacy of acyclovir in herpes simplex virus infections.Antimicrobial agents and chemotherapy · 2011Article
- Efficacy of CMX001 against herpes simplex virus infections in mice and correlations with drug distribution studies.The Journal of infectious diseases · 2010Article
- Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals.Antimicrobial agents and chemotherapy · 2010Article
- Article
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12 authors.
Funding
Abstract
A series of 4'-thionucleosides were synthesized and evaluated for activities against orthopoxviruses and herpesviruses. We reported previously that one analog, 5-iodo-4'-thio-2'-deoxyuridine (4'-thioIDU), exhibits good activity both in vitro and in vivo against two orthopoxviruses. This compound also has good activity in cell culture against many of the herpesviruses. It inhibited the replication of herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus with 50% effective concentrations (EC(50)s) of 0.1, 0.5, and 2 microM, respectively. It also inhibited the replication of human cytomegalovirus (HCMV) with an EC(50) of 5.9 microM but did not selectively inhibit Epstein-Barr virus, human herpesvirus 6, or human herpesvirus 8. While acyclovir-resistant strains of HSV-1 and HSV-2 were comparatively resistant to 4'-thioIDU, it retained modest activity (EC(50)s of 4 to 12 microM) against these strains. Some ganciclovir-resistant strains of HCMV also exhibited reduced susceptibilities to the compound, which appeared to be related to the specific mutations in the DNA polymerase, consistent with the observed incorporation of the compound into viral DNA. The activity of 4'-thioIDU was also evaluated using mice infected intranasally with the MS strain of HSV-2. Although there was no decrease in final mortality rates, the mean length of survival after inoculation increased significantly (P < 0.05) for all animals receiving 4'-thioIDU. The findings from the studies presented here suggest that 4'-thioIDU is a good inhibitor of some herpesviruses, as well as orthopoxviruses, and this class of compounds warrants further study as a therapy for infections with these viruses.
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