ArticleThe Journal of physiology2009
Hypoxia reduces the hypothalamic thermogenic threshold and thermosensitivity.
Article in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 70 citations in OpenAlex.
- Independent and combined impact of hypoxia and acute inorganic nitrate ingestion on thermoregulatory responses to the cold.European journal of applied physiology · 2021Trial
- Development of a predictive score for hypothermia risk during continuous kidney replacement therapy in critically ill patients.Renal failure · 2026Article
- Revisiting concepts of thermal physiology: understanding negative feedback and set-point in mammals, birds, and lizards.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Common tenrecs (Tenrec ecaudatus) reduce oxygen consumption in hypoxia and in hypercapnia without concordant changes to body temperature or heart rate.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Exercise derived myokine irisin as mediator of cardiorespiratory, metabolic and thermal adjustments during central and peripheral chemoreflex activation.Scientific reports · 2024Article
- Hypothermia amongst neonatal admissions in Kenya: a retrospective cohort study assessing prevalence, trends, associated factors, and its relationship with all-cause neonatal mortality.Frontiers in pediatrics · 2024Article
- Physiological responses to hypoxia are constrained by environmental temperature in heterothermic tenrecs.The Journal of experimental biology · 2023Article
- Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1.Nature communications · 2021Article
- Correlation between convection requirement and carotid body responses to hypoxia and hemoglobin affinity: comparison between two rat strains.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Hypoxia gradually augments metabolic and thermoperceptual responsiveness to repeated whole-body cold stress in humans.Experimental physiology · 2020Article
- Combined stimuli of cold, hypoxia, and dehydration status on body temperature in rats: a pilot study with practical implications for humans.BMC research notes · 2020Article
- Article
- Ventilatory, metabolic, and thermoregulatory responses of Damaraland mole rats to acute and chronic hypoxia.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Article
- TRPV1 Inhibits the Ventilatory Response to Hypoxia in Adult Rats, but Not the CO₂-Drive to Breathe.Pharmaceuticals (Basel, Switzerland) · 2019Article
- Hypoxia, hibernation and Neuroprotection: An Experimental Study in Mice.Aging and disease · 2018Article
- Short-Term Sustained Hypoxia Elevates Basal and Hypoxia-Induced Ventilation but Not the Carotid Body Chemoreceptor Activity in Rats.Frontiers in physiology · 2018Article
- Does Hypoxia Decrease the Metabolic Rate?Frontiers in endocrinology · 2018Review
- Hypometabolism and hypothermia in the rat model of endotoxic shock: independence of circulatory hypoxia.The Journal of physiology · 2014Article
- The vesicular glutamate transporter VGLUT3 contributes to protection against neonatal hypoxic stress.The Journal of physiology · 2012Article
- Short of air? Cool it!The Journal of physiology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypoxia is well known to reduce the body temperature (T(b)) of mammals, although the neural origins of this response remain uncertain. Short-term hypoxic exposure causes a reduction in the lower critical temperature of the thermal neutral zone and a reduction in whole body thermal conductance of rodents, providing indirect support that hypoxia lowers T(b) in a regulated manner. In this study, we examined directly the potential for changes in central thermosensitivity to evoke the hypoxic metabolic response by heating and cooling the preoptic area of the hypothalamus (the area which integrates thermoreceptor input and regulates thermoeffector outputs) using chronic, indwelling thermodes in ground squirrels during normoxia and hypoxia (7, 10 and 12% O(2)). We found that the threshold hypothalamic temperature for the metabolic response to cooling (T(th)) of approximately 38 degrees C in normoxia was proportionately reduced in hypoxia (down to 28-31 degrees C at 7% O(2)) and that the metabolic thermosensitivity (alpha; the change in metabolic rate for any given change in hypothalamic temperature below the lower critical temperature) was comparatively reduced by 5 to 9 times. This provides strong support for the hypothesis that the fall in temperature that occurs during hypoxia is the result of a reduction in the activation of thermogenic mechanisms. The decrease in the central thermosensitivity in hypoxia, however, appears to be a critical factor in the alteration of mammalian T(b). We suggest, therefore, that an altered central thermosensitivity may provide a proximate explanation of how low oxygen and similar stressors reduce normal fluctuations in T(b) (i.e. circadian), in addition to the depression in regulated T(b).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.