ReviewNeurobiology of disease2010
Translating the frontiers of brain repair to treatments: starting not to break the rules.
Review in Neurobiology of disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Show Me Your Friends and I Tell You Who You Are: The Many Facets of Prion Protein in Stroke.Cells · 2020Review
- Buyang Huanwu decoction facilitates neurorehabilitation through an improvement of synaptic plasticity in cerebral ischemic rats.BMC complementary and alternative medicine · 2017Article
- GDF10 is a signal for axonal sprouting and functional recovery after stroke.Nature neuroscience · 2015Article
- Frontiers in therapeutic development of allopregnanolone for Alzheimer's disease and other neurological disorders.Frontiers in cellular neuroscience · 2014Review
- Article
- Emerging molecular targets for brain repair after stroke.Stroke research and treatment · 2013Article
- Is sleep essential for neural plasticity in humans, and how does it affect motor and cognitive recovery?Neural plasticity · 2013Review
- Intravascular stem cell transplantation for stroke.Translational stroke research · 2011Article
- Article
- The immunology of stroke: from mechanisms to translation.Nature medicine · 2011Review
- Targets for neural repair therapies after stroke.Stroke · 2010Review
- Beyond neuroprotection to brain repair: exploring the next frontier in clinical neuroscience to expand the therapeutic window for stroke.Translational stroke research · 2010Article
- Promoting axonal rewiring to improve outcome after stroke.Neurobiology of disease · 2010Review
- Optimizing the success of cell transplantation therapy for stroke.Neurobiology of disease · 2010Review
- Recovery of function in humans: cortical stimulation and pharmacological treatments after stroke.Neurobiology of disease · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The field of neural repair in stroke has identified cellular systems of reorganization and possible molecular mechanisms. Conceptual barriers now limit the generation of clinically useful agents. First, it is not clear what the causal mechanisms of neural repair are in stroke. Second, adequate delivery systems for neural repair drugs need to be determined for candidate molecules. Third, ad hoc applications of existing pharmacological agents that enhance attention, mood or arousal to stroke have failed. New approaches that specifically harness the molecular systems of learning and memory provide a new avenue for stroke repair drugs. Fourth, combinatorial treatments for neural repair need to be considered for clinical therapies. Finally, neural repair therapies have as a goal altering brain connections, cognitive maps and active neural networks. These actions may trigger a unique set of "neural repair side effects" that need to be considered in planning clinical trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.