ArticleACS nano2009
Exposure to titanium dioxide nanomaterials provokes inflammation of an in vitro human immune construct.
Article in ACS nano, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04557345 (Evaluation of the Inflammatory Response and Long-term Calcification in Post-operated Aortic Valve Replacement Patients.), which is not on this map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Inflammatory Response and Long-term Calcification in Post-operated Aortic Valve Replacement Patients.
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Titanium dioxide nanoparticles: revealing the mechanisms underlying hepatotoxicity and effects in the gut microbiota.Archives of toxicology · 2023Pooled it
- Bioprosthesis in aortic valve replacement: long-term inflammatory response and functionality.Open heart · 2022Trial
- A Novel Microfluidic System for 3D Epidermis and Full-Thickness Skin Growth for Nanoparticle Safety Assessment.Advanced healthcare materials · 2026Article
- Molybdenum-bridged endo-exogenous antioxidant synergy reverses acute kidney injury via mitochondrial homeostasis reconstruction.Bioactive materials · 2025Article
- Evaluating immunohistochemical and genetic expression of green-mediated nano-enhanced glass ionomer cement: An animal model study.Journal of conservative dentistry and endodontics · 2025Article
- Article
- Recent applications of immunomodulatory biomaterials for disease immunotherapy.Exploration (Beijing, China) · 2022Review
- Narrative review on century of respiratory pandemics from Spanish flu to COVID-19 and impact of nanotechnology on COVID-19 diagnosis and immune system boosting.Virology journal · 2022Review
- Harnessing rat derived model cells to assess the toxicity of TiOJournal of materials science. Materials in medicine · 2022Article
- A New Look at the Effects of Engineered ZnO and TiONanomaterials (Basel, Switzerland) · 2022Review
- Collection of Controlled Nanosafety Data-The CoCoN-Database, a Tool to Assess Nanomaterial Hazard.Nanomaterials (Basel, Switzerland) · 2022Article
- Drosophila as a Suitable In Vivo Model in the Safety Assessment of Nanomaterials.Advances in experimental medicine and biology · 2022Article
- Particle Safety Assessment in Additive Manufacturing: From Exposure Risks to Advanced Toxicology Testing.Frontiers in toxicology · 2022Review
- Metallic Nanoparticle-Mediated Immune Cell Regulation and Advanced Cancer Immunotherapy.Pharmaceutics · 2021Review
- Advances in technology and applications of nanoimmunotherapy for cancer.Biomarker research · 2021Review
- Titanium dioxide particles from the diet: involvement in the genesis of inflammatory bowel diseases and colorectal cancer.Particle and fibre toxicology · 2021Review
- Dietary Nanoparticles Interact with Gluten Peptides and Alter the Intestinal Homeostasis Increasing the Risk of Celiac Disease.International journal of molecular sciences · 2021Article
- A Protein and Membrane Integrity Study of TiOThe Journal of membrane biology · 2021Article
- Impacts of foodborne inorganic nanoparticles on the gut microbiota-immune axis: potential consequences for host health.Particle and fibre toxicology · 2020Review
- Effects of Metal Oxide Nanoparticles on Toll-Like Receptor mRNAs in Human Monocytes.Nanomaterials (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Nanoparticle technology is undergoing significant expansion largely because of the potential of nanoparticles as biomaterials, drug delivery vehicles, cancer therapeutics, and immunopotentiators. Incorporation of nanoparticle technologies for in vivo applications increases the urgency to characterize nanomaterial immunogenicity. This study explores titanium dioxide, one of the most widely manufactured nanomaterials, synthesized into its three most common nanoarchitectures: anatase (7-10 nm), rutile (15-20 nm), and nanotube (10-15 nm diameters, 70-150 nm length). The fully human autologous MIMIC immunological construct has been utilized as a predictive, nonanimal alternative to diagnose nanoparticle immunogenicity. Cumulatively, treatment with titanium dioxide nanoparticles in the MIMIC system led to elevated levels of proinflammatory cytokines and increased maturation and expression of costimulatory molecules on dendritic cells. Additionally, these treatments effectively primed activation and proliferation of naive CD4(+) T cells in comparison to dendritic cells treated with micrometer-sized (>1 microm) titanium dioxide, characteristic of an in vivo inflammatory response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.