ArticleMolecular biology reports2010
Effects of integrins on laminin chemotaxis by hepatocellular carcinoma cells.
Article in Molecular biology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Decreased B4GALT1 promotes hepatocellular carcinoma cell invasiveness by regulating the laminin-integrin pathway.Oncogenesis · 2023Article
- Microarray analysis for the identification of specific proteins and functional modules involved in the process of hepatocellular carcinoma originating from cirrhotic liver.Molecular medicine reports · 2018Article
- miR-128 modulates hepatocellular carcinoma by inhibition of ITGA2 and ITGA5 expression.American journal of translational research · 2015Article
- Hepatitis C virus infection: establishment of chronicity and liver disease progression.EXCLI journal · 2014Review
- Protumoral roles of melanoma inhibitory activity 2 in oral squamous cell carcinoma.British journal of cancer · 2013Article
- Fibrosis-dependent mechanisms of hepatocarcinogenesis.Hepatology (Baltimore, Md.) · 2012Review
- Down-regulation of β3-integrin inhibits bone metastasis of small cell lung cancer.Molecular biology reports · 2012Article
- Article
- Effects of integrin α6β1 on migration of hepatocellular carcinoma cells.Molecular biology reports · 2011Article
- Loss of heterozygosity of the tumor suppressor gene Tg737 in the side population cells of hepatocellular carcinomas is associated with poor prognosis.Molecular biology reports · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To quantitatively evaluate the effects of integrins alpha1beta1, alpha2beta1, alpha3beta1, alpha4beta1, alpha5beta1, and alpha6beta1 on the chemotaxis of hepatocelluar carcinoma (HCC) cell line SMMC-7721 to laminin (LN). A modified dual-micropipette system was used to dynamically and quantitatively monitor the formation of pseudopod protrusion of HCC cells toward LN in the presence or absence of specific antibodies against integrins alpha1, alpha2, alpha3, alpha4, alpha5, alpha6, and beta1. Additionally, the expression levels of different integrin subunits on the surface of the cells were determined via flow cytometry analysis. In response to equal concentrations of LN in both micropipettes, HCC cells form symmetrical pseudopod protrusions on both sides. Addition of antibodies against alpha3, alpha6, or beta1 into one micropipette leads to significant reduction of pseudopod formation on that side, while antibodies against alpha1, alpha2, alpha4, and alpha5 do not affect the symmetrical formation of pseudopods in either micropipette. The percentages of HCC cells positive for expression of integrins alpha1, alpha2, alpha3, alpha4, alpha5, alpha6, and beta1 were 95.07, 23.17, 95.55, 2.47, 34, 14.29, and 95.78%, respectively. Integrins alpha3beta1 and alpha6beta1 are important cell surface receptors that mediate the chemotaxis of HCC cells toward LN.
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