ArticleCognitive neurodynamics2010
Effects of the anesthetic agent propofol on neural populations.
Article in Cognitive neurodynamics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Anesthetic action on the transmission delay between cortex and thalamus explains the beta-buzz observed under propofol anesthesia.PloS one · 2017Trial
- Bifurcations and Hyperchaos in Mathematical Models of Sleep.Bioengineering (Basel, Switzerland) · 2026Review
- Criticality supports cross-frequency cortical-thalamic information transfer during conscious states.eLife · 2024Article
- Unveiling age-independent spectral markers of propofol-induced loss of consciousness by decomposing the electroencephalographic spectrum into its periodic and aperiodic components.Frontiers in aging neuroscience · 2022Article
- Computational Models in Electroencephalography.Brain topography · 2022Review
- Determinants of Brain Rhythm Burst Statistics.Scientific reports · 2019Article
- Optimal Model Parameter Estimation from EEG Power Spectrum Features Observed during General Anesthesia.Neuroinformatics · 2018Article
- Characterizing Awake and Anesthetized States Using a Dimensionality Reduction Method.Journal of medical systems · 2016Article
- A Mechanistic Neural Field Theory of How Anesthesia Suppresses Consciousness: Synaptic Drive Dynamics, Bifurcations, Attractors, and Partial State Equipartitioning.Journal of mathematical neuroscience · 2015Article
- How the cortico-thalamic feedback affects the EEG power spectrum over frontal and occipital regions during propofol-induced sedation.Journal of computational neuroscience · 2015Article
- Monitoring depth of anesthesia using combination of EEG measure and hemodynamic variables.Cognitive neurodynamics · 2015Article
- A Pharmacokinetics-Neural Mass Model (PK-NMM) for the Simulation of EEG Activity during Propofol Anesthesia.PloS one · 2015Article
- Study of GABAergic extra-synaptic tonic inhibition in single neurons and neural populations by traversing neural scales: application to propofol-induced anaesthesia.Journal of computational neuroscience · 2014Article
- From data patterns to mechanistic models in acute critical illness.Journal of critical care · 2014Review
- Modeling the dynamical effects of anesthesia on brain circuits.Current opinion in neurobiology · 2014Review
- Emergence from general anesthesia and the sleep-manifold.Frontiers in systems neuroscience · 2014Article
- Engineering a thalamo-cortico-thalamic circuit on SpiNNaker: a preliminary study toward modeling sleep and wakefulness.Frontiers in neural circuits · 2014Article
- Anesthetic action on extra-synaptic receptors: effects in neural population models of EEG activity.Frontiers in systems neuroscience · 2014Article
- Distributed nonlocal feedback delays may destabilize fronts in neural fields, distributed transmission delays do not.Journal of mathematical neuroscience · 2013Article
- Phase-locking of epileptic spikes to ongoing delta oscillations in non-convulsive status epilepticus.Frontiers in systems neuroscience · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neuronal mechanisms of general anesthesia are still poorly understood. Besides several characteristic features of anesthesia observed in experiments, a prominent effect is the bi-phasic change of power in the observed electroencephalogram (EEG), i.e. the initial increase and subsequent decrease of the EEG-power in several frequency bands while increasing the concentration of the anaesthetic agent. The present work aims to derive analytical conditions for this bi-phasic spectral behavior by the study of a neural population model. This model describes mathematically the effective membrane potential and involves excitatory and inhibitory synapses, excitatory and inhibitory cells, nonlocal spatial interactions and a finite axonal conduction speed. The work derives conditions for synaptic time constants based on experimental results and gives conditions on the resting state stability. Further the power spectrum of Local Field Potentials and EEG generated by the neural activity is derived analytically and allow for the detailed study of bi-spectral power changes. We find bi-phasic power changes both in monostable and bistable system regime, affirming the omnipresence of bi-spectral power changes in anesthesia. Further the work gives conditions for the strong increase of power in the δ-frequency band for large propofol concentrations as observed in experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.