ReviewNeuropsychology review2009
The impact of genetic research on our understanding of normal cognitive ageing: 1995 to 2009.
Review in Neuropsychology review, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).Molecular psychiatry · 2015Pooled it
- Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.Proceedings of the National Academy of Sciences of the United States of America · 2014Pooled it
- SH2B1 Tunes Hippocampal ERK Signaling to Influence Fluid Intelligence in Humans and Mice.Research (Washington, D.C.) · 2023Article
- The relationship between temperament, polygenic score for intelligence and cognition: A population-based study of middle-aged adults.Genes, brain, and behavior · 2022Article
- Systems genetics identifies Hp1bp3 as a novel modulator of cognitive aging.Neurobiology of aging · 2016Article
- Genetic variation and cognitive dysfunction in opioid-treated patients with cancer.Brain and behavior · 2016Article
- GWAS for executive function and processing speed suggests involvement of the CADM2 gene.Molecular psychiatry · 2016Article
- Genetic factors moderate everyday physical activity effects on executive functions in aging: Evidence from the Victoria Longitudinal Study.Neuropsychology · 2016Article
- Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium.Biological psychiatry · 2015Article
- Whole genome sequences of 2 octogenarians with sustained cognitive abilities.Neurobiology of aging · 2015Article
- Synergistic associations of catechol-O-methyltransferase and brain-derived neurotrophic factor with executive function in aging are selective and modified by apolipoprotein E.Neurobiology of aging · 2015Article
- No association between apolipoprotein E or N-acetyltransferase 2 gene polymorphisms and age-related hearing loss.The Laryngoscope · 2015Article
- DUF1220 copy number is linearly associated with increased cognitive function as measured by total IQ and mathematical aptitude scores.Human genetics · 2015Article
- Genome-Wide Analyses of Working-Memory Ability: A Review.Current behavioral neuroscience reports · 2014Article
- Efficiency of weak brain connections support general cognitive functioning.Human brain mapping · 2014Article
- APOE and COMT polymorphisms are complementary biomarkers of status, stability, and transitions in normal aging and early mild cognitive impairment.Frontiers in aging neuroscience · 2014Article
- Schooling and variation in the COMT gene: the devil is in the details.Journal of child psychology and psychiatry, and allied disciplines · 2013Article
- Common DNA markers can account for more than half of the genetic influence on cognitive abilities.Psychological science · 2013Article
- The Promises and Pitfalls of Genoeconomics*Annual review of economics · 2012Article
- Lack of exercise is a major cause of chronic diseases.Comprehensive Physiology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identifying the risk factors for individual differences in age-related cognitive ability and decline is amongst the greatest challenges facing the healthcare of older people. Cognitive impairment caused by "normal ageing" is a major contributor towards overall cognitive deficit in the elderly and a process that exhibits substantial inter- and intra-individual differences. Both cognitive ability and its decline with age are influenced by genetic variation that may act independently or via epistasis/gene-environment interaction. Over the past fourteen years genetic research has aimed to identify the polymorphisms responsible for high cognitive functioning and successful cognitive ageing. Unfortunately, during this period a bewildering array of contrasting reports have appeared in the literature that have implicated over 50 genes with effect sizes ranging from 0.1 to 21%. This review will provide a comprehensive account of the studies performed on cognitively healthy individuals, from the first study conducted in 1995 to present. Based on current knowledge the strong and weak methodologies will be identified and suggestions for future study design will be presented.
Indexed as
Identifiers
19768548What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.