ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2010
Cisplatin interaction with phosphatidylserine bilayer studied by solid-state NMR spectroscopy.
Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- Effect of Cisplatin and Its Cationic Analogues in the Phase Behavior and Permeability of Model Lipid Bilayers.Molecular pharmaceutics · 2023Article
- Lipid imaging for visualizing cilastatin amelioration of cisplatin-induced nephrotoxicity.Journal of lipid research · 2018Article
- Cisplatin-Membrane Interactions and Their Influence on Platinum Complexes Activity and Toxicity.Frontiers in physiology · 2018Review
- Mesenchymal stem cells maintain their defining stem cell characteristics after treatment with cisplatin.Scientific reports · 2016Article
- MG53-mediated cell membrane repair protects against acute kidney injury.Science translational medicine · 2015Article
- Article
- Knock down of p53 or its ubiquitin ligase E6AP does not affect the sensitivity of human papillomavirus-positive cervical cancer cells to cisplatin.American journal of cancer research · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cisplatin [cis-diamminedichloridoplatinum(II)] is used in chemotherapy where platinum-DNA adducts initiate tumor cell death. It is possible that side effects such as neurotoxicity and cellular cisplatin resistance can be due to interaction of cisplatin with lipids and the phospholipid bilayer. In this study, (13)C, (31)P, and (15)N solid-state NMR spectra of 1-palmitoyl-2-oleoyl phosphatidylserine (POPS) bilayers, POPS bilayers with 10 mol% cisplatin, and POPS bilayers with 30 mol% cisplatin were acquired. In addition, (15)N{(31)P} rotational echo double resonance spectra of POPS bilayers with 30 mol% cisplatin were acquired. The data demonstrate that the serine head group of phosphatidylserine binds to the aquated form of cisplatin and that cisplatin release of ammine takes place. It appears that the cisplatin release of ammine is followed by another cisplatin-POPS complex formation, possibly with cisplatin binding to one of the oxygen atoms of the POPS phosphate moiety.
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