ArticlePloS one2009
Transcriptional profiling of Bacillus anthracis Sterne (34F2) during iron starvation.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Mixed heavy metal stress induces global iron starvation response.The ISME journal · 2023Article
- Heme catabolism in the causative agent of anthrax.Molecular microbiology · 2019Article
- Transcriptional response of Clostridium difficile to low iron conditions.Pathogens and disease · 2018Article
- Petrobactin Is Exported frommBio · 2017Article
- Heme Synthesis and Acquisition in Bacterial Pathogens.Journal of molecular biology · 2016Review
- Changes in Bacillus anthracis CodY regulation under host-specific environmental factor deprived conditions.BMC genomics · 2016Article
- Global gene expression by Bacillus anthracis during growth in mammalian blood.Pathogens and disease · 2015Article
- Expression of three topologically distinct membrane proteins elicits unique stress response pathways in the yeast Saccharomyces cerevisiae.Physiological genomics · 2015Article
- Whole genome protein microarrays for serum profiling of immunodominant antigens of Bacillus anthracis.Frontiers in microbiology · 2015Article
- BOG: R-package for Bacterium and virus analysis of Orthologous Groups.Computational and structural biotechnology journal · 2015Article
- Iron acquisition in Bacillus cereus: the roles of IlsA and bacillibactin in exogenous ferritin iron mobilization.PLoS pathogens · 2014Article
- IruO is a reductase for heme degradation by IsdI and IsdG proteins in Staphylococcus aureus.The Journal of biological chemistry · 2013Article
- Hal Is a Bacillus anthracis heme acquisition protein.Journal of bacteriology · 2012Article
- Multiple ABC transporters are involved in the acquisition of petrobactin in Bacillus anthracis.Molecular microbiology · 2012Article
- Metalloregulation of Gram-positive pathogen physiology.Current opinion in microbiology · 2012Review
- Strand-specific RNA-seq reveals ordered patterns of sense and antisense transcription in Bacillus anthracis.PloS one · 2012Article
- Differential function of lip residues in the mechanism and biology of an anthrax hemophore.PLoS pathogens · 2012Article
- Structural basis for hemoglobin capture by Staphylococcus aureus cell-surface protein, IsdH.The Journal of biological chemistry · 2011Article
- The five near-iron transporter (NEAT) domain anthrax hemophore, IsdX2, scavenges heme from hemoglobin and transfers heme to the surface protein IsdC.The Journal of biological chemistry · 2011Article
- Regulation of petrobactin and bacillibactin biosynthesis in Bacillus anthracis under iron and oxygen variation.PloS one · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Lack of available iron is one of many environmental challenges that a bacterium encounters during infection and adaptation to iron starvation is important for the pathogen to efficiently replicate within the host. Here we define the transcriptional response of B. anthracis Sterne (34F(2)) to iron depleted conditions. Genome-wide transcript analysis showed that B. anthracis undergoes considerable changes in gene expression during growth in iron-depleted media, including the regulation of known and candidate virulence factors. Two genes encoding putative internalin proteins were chosen for further study. Deletion of either gene (GBAA0552 or GBAA1340) resulted in attenuation in a murine model of infection. This attenuation was amplified in a double mutant strain. These data define the transcriptional changes induced during growth in low iron conditions and illustrate the potential of this dataset in the identification of putative virulence determinants for future study.
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