ArticleOncogene2009
Heat shock protein 27 mediates repression of androgen receptor function by protein kinase D1 in prostate cancer cells.
Article in Oncogene, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Review
- FYN/TOPK/HSPB1 axis facilitates the proliferation and metastasis of gastric cancer.Journal of experimental & clinical cancer research : CR · 2023Article
- Regulation of Osteoclast Differentiation at Multiple Stages by Protein Kinase D Family Kinases.International journal of molecular sciences · 2020Article
- eIF4E Phosphorylation in Prostate Cancer.Neoplasia (New York, N.Y.) · 2018Review
- Androgen receptor and heat shock protein 27 co-regulate the malignant potential of molecular apocrine breast cancer.Journal of experimental & clinical cancer research : CR · 2018Article
- Beta-catenin represses protein kinase D1 gene expression by non-canonical pathway through MYC/MAX transcription complex in prostate cancer.Oncotarget · 2017Article
- Protein kinase D signaling in cancer: A friend or foe?Biochimica et biophysica acta. Reviews on cancer · 2017Review
- Article
- Cell line modeling to study biomarker panel in prostate cancer.The Prostate · 2016Article
- Article
- Article
- Protein kinase D1 attenuates tumorigenesis in colon cancer by modulating β-catenin/T cell factor activity.Oncotarget · 2014Article
- In vitro cytotoxicity, pharmacokinetics, tissue distribution, and metabolism of small-molecule protein kinase D inhibitors, kb-NB142-70 and kb-NB165-09, in mice bearing human cancer xenografts.Cancer chemotherapy and pharmacology · 2013Article
- Effect of the heat shock protein HSP27 on androgen receptor expression and function in prostate cancer cells.World journal of urology · 2012Article
- Curcumin attenuates β-catenin signaling in prostate cancer cells through activation of protein kinase D1.PloS one · 2012Article
- Emerging roles of protein kinase D1 in cancer.Molecular cancer research : MCR · 2011Review
- Role of protein kinase D signaling in pancreatic cancer.Biochemical pharmacology · 2010Review
- Protein kinase D as a potential new target for cancer therapy.Biochimica et biophysica acta · 2010Review
- Protein kinase D1 inhibits cell proliferation through matrix metalloproteinase-2 and matrix metalloproteinase-9 secretion in prostate cancer.Cancer research · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously shown that protein kinase D1 (PKD1), charter member of PKD protein family, is downregulated in advanced prostate cancer (PC) and influences androgen receptor (AR) function in PC cells. Other independent studies showed that serine 82 residue in heat shock protein 27 (Hsp27) undergoes substrate phosphorylation by PKD1 and is associated with nuclear transport of AR resulting in increased AR transcriptional activity. In this study, we show that PKD1 interacts and phosphorylates Hsp27 at Ser82 in PC cells, which is mediated by p38-dependent mitogen-activated protein kinase pathway and is necessary for PKD1 repression of AR transcriptional activity and androgen-dependent proliferation of PC cells. The study provides first in vivo evidence that Hsp27 is a mediator of repression of AR function by PKD1 in PC cells, thereby linking the data in the published literature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.