ArticleNature genetics2009
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
Article in Nature genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 263 papers, 14 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
263 citing papers in PubMed, 14 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Pooled it
- First-degree family history of breast cancer is associated with prostate cancer risk: a systematic review and meta-analysis.BMC cancer · 2019Pooled it
- Discovery of common and rare genetic risk variants for colorectal cancer.Nature genetics · 2019Pooled it
- The association between IGF1 Gene 3'-UTR polymorphisms and cancer risk: A Meta-analysis.Medicine · 2018Pooled it
- Five endometrial cancer risk loci identified through genome-wide association analysis.Nature genetics · 2016Pooled it
- A genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population.Oncotarget · 2016Pooled it
- A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk.Cancer research · 2016Pooled it
- A genome-wide pleiotropy scan for prostate cancer risk.European urology · 2015Pooled it
- Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium.Human genetics · 2015Pooled it
- Cross-cancer pleiotropic analysis of endometrial cancer: PAGE and E2C2 consortia.Carcinogenesis · 2014Pooled it
- Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Pooled it
- GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.Science (New York, N.Y.) · 2013Pooled it
- Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry.Human genetics · 2012Pooled it
- Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese.Nature genetics · 2012Pooled it
- Genome-wide association study identifies pharmacogenomic loci linked with specific antihypertensive drug treatment and new-onset diabetes.The pharmacogenomics journal · 2018Trial
- Reclassification of prostate cancer risk using sequentially identified SNPs: Results from the REDUCE trial.The Prostate · 2017Trial
- The G84E mutation of HOXB13 is associated with increased risk for prostate cancer: results from the REDUCE trial.Carcinogenesis · 2013Trial
- A novel germline mutation in HOXB13 is associated with prostate cancer risk in Chinese men.The Prostate · 2013Trial
- Decoding the germline genetic architecture of prostate cancer at a single cell resolution.PLoS genetics · 2025Article
- Decoding ancestry-specific genetic risk: interpretable deep feature selection reveals prostate cancer SNP disparities in diverse populations.BioData mining · 2025Article
203 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
104 authors at 1 institution in 1 country.
Funding
Abstract
Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 x 10(-8) to P = 2.7 x 10(-33)).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.