Trial reportAmerican journal of physiology. Heart and circulatory physiology2009
Antioxidants and aging: NMR-based evidence of improved skeletal muscle perfusion and energetics.
Trial report in American journal of physiology. Heart and circulatory physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures.Archives of neurology · 2012Trial
- Nitric oxide, but not vasodilating prostaglandins, contributes to the improvement of exercise hyperemia via ascorbic acid in healthy older adults.American journal of physiology. Heart and circulatory physiology · 2010Trial
- Insights into vitamin C in musculoskeletal physiology and disorders: mechanisms and translational perspectives.Frontiers in immunology · 2026Review
- Roadmap for alleviating the manifestations of ageing in the cardiovascular system.Nature reviews. Cardiology · 2025Review
- Interleaved and simultaneous multi-nuclear magnetic resonance in vivo. Review of principles, applications and potential.NMR in biomedicine · 2022Review
- Lifelong Endurance Exercise as a Countermeasure Against Age-RelatedSports medicine (Auckland, N.Z.) · 2020Review
- Impact of acute antioxidant administration on inflammation and vascular function in heart failure with preserved ejection fraction.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Using MRI to measure in vivo free radical production and perfusion dynamics in a mouse model of elevated oxidative stress and neurogenic atrophy.Redox biology · 2019Article
- Impaired Muscle Efficiency but Preserved Peripheral Hemodynamics and Mitochondrial Function With Advancing Age: Evidence From Exercise in the Young, Old, and Oldest-Old.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Article
- Oral antioxidants improve leg blood flow during exercise in patients with chronic obstructive pulmonary disease.American journal of physiology. Heart and circulatory physiology · 2015Article
- Evidence of Preserved Oxidative Capacity and Oxygen Delivery in the Plantar Flexor Muscles With Age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Ascorbic acid attenuates the pressor response to voluntary apnea in postmenopausal women.Physiological reports · 2015Article
- Positron emission tomography detects greater blood flow and less blood flow heterogeneity in the exercising skeletal muscles of old compared with young men during fatiguing contractions.The Journal of physiology · 2014Article
- Effect of age on in vivo oxidative capacity in two locomotory muscles of the leg.Age (Dordrecht, Netherlands) · 2014Article
- Vitamin E in sarcopenia: current evidences on its role in prevention and treatment.Oxidative medicine and cellular longevity · 2014Review
- Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials.The international journal of biochemistry & cell biology · 2013Review
- Muscle metabolism and activation heterogeneity by combined 31P chemical shift and T2 imaging, and pulmonary O2 uptake during incremental knee-extensor exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Reduced muscle oxidative capacity is independent of O2 availability in elderly people.Age (Dordrecht, Netherlands) · 2013Article
- Oxidative stress and COPD: the effect of oral antioxidants on skeletal muscle fatigue.Medicine and science in sports and exercise · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We sought to examine the potential role of oxidative stress on skeletal muscle function with advancing age. Nuclear magnetic resonance (NMR) was employed to simultaneously assess muscle perfusion (arterial spin labeling) and energetics ((31)P NMR spectroscopy) in the lower leg of young (26 + or - 5 yr, n = 6) and older (70 + or - 5 yr, n = 6) healthy volunteers following the consumption of either placebo (PL) or an oral antioxidant (AO) cocktail (vitamins C and E and alpha-lipoic acid), previously documented to decrease plasma free radical concentration. NMR measurements were made during and after 5 min of moderate intensity (approximately 5 W) plantar flexion exercise. AO administration significantly improved end-exercise perfusion (AO, 50 + or - 5, and PL, 43 + or - 4 ml x 100 g(-1) x min(-1)) and postexercise perfusion area under the curve (AO, 1,286 + or - 236, and PL, 866 + or - 144 ml/100 g) in older subjects, whereas AO administration did not alter hemodynamics in the young group. Concomitantly, muscle oxidative capacity (time constant of phosphocreatine recovery, tau) was improved following AO in the older (AO, 43 + or - 1, and PL, 51 + or - 7 s) but not the young (AO, 54 + or - 5, and PL, 48 + or - 7 s) group. These findings support the concept that oxidative stress may be partially responsible for the age-related decline in skeletal muscle perfusion during physical activity and reveal a muscle metabolic reserve capacity in the elderly that is accessible under conditions of improved perfusion.
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Registered trials
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