ArticleMechanisms of development2009
The Drosophila Activin-like ligand Dawdle signals preferentially through one isoform of the Type-I receptor Baboon.
Article in Mechanisms of development, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- Glycogen homeostasis and mitochondrial DNA expression require motor neuron to muscle TGF-β/Activin signaling in Drosophila.iScience · 2025Article
- Article
- Glycogen homeostasis and mtDNA expression require motor neuron to muscle TGFβ/Activin Signaling inbioRxiv : the preprint server for biology · 2024Article
- Review
- Drosophila activins adapt gut size to food intake and promote regenerative growth.Nature communications · 2024Article
- Article
- Regulating metabolism to shape immune function: Lessons from Drosophila.Seminars in cell & developmental biology · 2023Review
- The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulateseLife · 2022Article
- Muscle-derived Myoglianin regulateseLife · 2020Article
- Visualization of Endogenous Type I TGF-β Receptor Baboon in the Drosophila Brain.Scientific reports · 2020Article
- Article
- Alternative cleavage of the bone morphogenetic protein (BMP), Gbb, produces ligands with distinct developmental functions and receptor preferences.The Journal of biological chemistry · 2017Article
- TGF-β Family Signaling inCold Spring Harbor perspectives in biology · 2017Review
- Parallel Activin and BMP signaling coordinates R7/R8 photoreceptor subtype pairing in the stochasticeLife · 2017Article
- Optimized strategy for in vivo Cas9-activation inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Midgut-Derived Activin Regulates Glucagon-like Action in the Fat Body and Glycemic Control.Cell metabolism · 2017Article
- TGFβ/Activin signalling is required for ribosome biogenesis and cell growth in Drosophila salivary glands.Open biology · 2017Article
- CTCF-dependent co-localization of canonical Smad signaling factors at architectural protein binding sites in D. melanogaster.Cell cycle (Georgetown, Tex.) · 2015Article
- Strategies for exploring TGF-β signaling in Drosophila.Methods (San Diego, Calif.) · 2014Review
- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
How TGF-beta-type ligands achieve signaling specificity during development is only partially understood. Here, we show that Dawdle, one of four Activin-type ligands in Drosophila, preferentially signals through Babo(c), one of three isoforms of the Activin Type-I receptor that are expressed during development. In cell culture, Dawdle signaling is active in the presence of the Type-II receptor Punt but not Wit, demonstrating that the Type-II receptor also contributes to the specificity of the signaling complex. During development, different larval tissues express unique combinations of these receptors, and ectopic expression of Babo(c) in a tissue where it is not normally expressed at high levels can make that tissue sensitive to Dawdle signaling. These results reveal a mechanism by which distinct cell types can discriminate between different Activin-type signals during development as a result of differential expression of Type-I receptor isoforms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.