ArticleDevelopmental biology2009
Complex interactions amongst N-cadherin, DLAR, and Liprin-alpha regulate Drosophila photoreceptor axon targeting.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
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- Systematic analysis of the Frazzled receptor interactome establishes previously unreported regulators of axon guidance.Development (Cambridge, England) · 2023Article
- Evidence of genetic overlap and causal relationships between blood-based biochemical traits and human cortical anatomy.Translational psychiatry · 2022Article
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- Assembly of the presynaptic active zone.Current opinion in neurobiology · 2020Review
- Lar maintains the homeostasis of the hematopoietic organ inDevelopment (Cambridge, England) · 2019Article
- Two receptor tyrosine phosphatases dictate the depth of axonal stabilizing layer in the visual system.eLife · 2017Article
- The genetic basis for variation in resistance to infection in the Drosophila melanogaster genetic reference panel.PLoS pathogens · 2017Article
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- Functional Conservation of the Glide/Gcm Regulatory Network Controlling Glia, Hemocyte, and Tendon Cell Differentiation in Drosophila.Genetics · 2016Article
- Filopodial dynamics and growth cone stabilization in Drosophila visual circuit development.eLife · 2015Article
- Age-driven modulation of tRNA-derived fragments in Drosophila and their potential targets.Biology direct · 2015Article
- The role of cell adhesion molecules in visual circuit formation: from neurite outgrowth to maps and synaptic specificity.Developmental neurobiology · 2015Review
- Visual circuit assembly requires fine tuning of the novel Ig transmembrane protein Borderless.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
- Gogo receptor contributes to retinotopic map formation and prevents R1-6 photoreceptor axon bundling.PloS one · 2013Article
- Developmental changes in expression, subcellular distribution, and function of Drosophila N-cadherin, guided by a cell-intrinsic program during neuronal differentiation.Developmental biology · 2012Article
- The receptor tyrosine phosphatase Lar regulates adhesion between Drosophila male germline stem cells and the niche.Development (Cambridge, England) · 2012Article
- LAR receptor tyrosine phosphatases and HSPGs guide peripheral sensory axons to the skin.Current biology : CB · 2012Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
The formation of stable adhesive contacts between pre- and post-synaptic neurons represents the initial step in synapse assembly. The cell adhesion molecule N-cadherin, the receptor tyrosine phosphatase DLAR, and the scaffolding molecule Liprin-alpha play critical, evolutionarily conserved roles in this process. However, how these proteins signal to the growth cone and are themselves regulated remains poorly understood. Using Drosophila photoreceptors (R cells) as a model, we evaluate genetic and physical interactions among these three proteins. We demonstrate that DLAR function in this context is independent of phosphatase activity but requires interactions mediated by its intracellular domain. Genetic studies reveal both positive and, surprisingly, inhibitory interactions amongst all three genes. These observations are corroborated by biochemical studies demonstrating that DLAR physically associates via its phosphatase domain with N-cadherin in Drosophila embryos. Together, these data demonstrate that N-cadherin, DLAR, and Liprin-alpha function in a complex to regulate adhesive interactions between pre- and post-synaptic cells and provide a novel mechanism for controlling the activity of Liprin-alpha in the developing growth cone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.