Trial reportClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2009
Neurophysiologic assessment of brain maturation after an 8-week trial of skin-to-skin contact on preterm infants.
Trial report in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03316547 (Supporting and Enhancing NICU Sensory Experiences to Optimize Developmental Outcomes in Preterm Infants), which is not on this map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Supporting and Enhancing NICU Sensory Experiences to Optimize Developmental Outcomes in Preterm Infants
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Sensory modulation in preterm children: Theoretical perspective and systematic review.PloS one · 2017Pooled it
- Kangaroo Mother Care and Neonatal Outcomes: A Meta-analysis.Pediatrics · 2016Pooled it
- Randomized clinical trial investigating the effect of consistent, developmentally-appropriate, and evidence-based multisensory exposures in the NICU.Journal of perinatology : official journal of the California Perinatal Association · 2021Trial
- Effectiveness of the Close Collaboration with Parents intervention on parent-infant closeness in NICU.BMC pediatrics · 2021Trial
- Community initiated kangaroo mother care and early child development in low birth weight infants in India-a randomized controlled trial.BMC pediatrics · 2020Trial
- Parent-Training with Kangaroo Care Impacts Infant Neurophysiological Development & Mother-Infant Neuroendocrine Activity.Infant behavior & development · 2020Trial
- Influence of holding practice on preterm infant development.MCN. The American journal of maternal child nursingTrial
- Improving sleep duration in NICU graduates: a quality improvement initiative.BMJ open quality · 2026Article
- Exploration of factors affecting parent-infant closeness and separation in hospitals in Nepal - a qualitative study.BMC pregnancy and childbirth · 2026Article
- Early Relational Health and its Impact on the Developing Brain: A Scoping Review.Clinical child and family psychology review · 2026Article
- Influence of skin to skin contact on cardiac indices and cerebral perfusion-oxygenation in severely asphyxiated infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Review
- Description and evidence on the supporting and enhancing neonatal intensive care unit sensory experiences (SENSE) program.Acta paediatrica (Oslo, Norway : 1992) · 2025Review
- An interdisciplinary fetal neonatal neurology collaborative promotes integrative life-course brain health.Frontiers in neurology · 2025Review
- Neuropsychology and Electroencephalography in Rural Children at Neurodevelopmental Risk: A Scoping Review.Pediatric reports · 2023Article
- NICU Couplet Care: metrics to guide an evolving model of care.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- NICU sensory experiences associated with positive outcomes: an integrative review of evidence from 2015-2020.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Article
- Survey of Skin-to-Skin Contact with Obstetrics and Pediatric Nurses.Nursing reports (Pavia, Italy) · 2022Article
- Delivery room cuddles for extremely preterm babies and parents: concept, practice, safety, parental feedback.Acta paediatrica (Oslo, Norway : 1992) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveSkin-to-skin contact (SSC) promotes physiological stability and interaction between parents and infants. Analyses of EEG-sleep studies can compare functional brain maturation between SSC and non-SSC cohorts.
methodsSixteen EEG-sleep studies were performed on eight preterm infants who received 8 weeks of SSC, and compared with two non-SSC cohorts at term (N=126), a preterm group corrected to term age and a full-term group. Seven linear and two complexity measures were compared (Mann-Whitney U test comparisons p<.05).
resultsFewer REMs, more quiet sleep, increased respiratory regularity, longer cycles, and less spectral beta were noted for SSC preterm infants compared with both control cohorts. Fewer REMs, greater arousals and more quiet sleep were noted for SSC infants compared with the non-SSC preterms at term. Three right hemispheric regions had greater complexity in the SSC group. Discriminant analysis showed that the SSC cohort was closer to the non-SSC full-term cohort.
conclusionsSkin-to-skin contact accelerates brain maturation in healthy preterm infants compared with two groups without SSC. SIGNIFICANCE: Combined use of linear and complexity analysis strategies offer complementary information regarding altered neuronal functions after developmental care interventions. Such analyses may be helpful to assess other neuroprotection strategies.
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