ArticleCurrent biology : CB2009
Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP(3) receptors.
Article in Current biology : CB, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 122 citations in OpenAlex.
- STIM-IP3R crosstalk regulates migration of breast cancer cells.The Journal of cell biology · 2025Article
- Plasma membrane curvature regulates the formation of contacts with the endoplasmic reticulum.Nature cell biology · 2024Article
- Membrane Curvature Promotes ER-PM Contact Formation via Junctophilin-EHD Interactions.bioRxiv : the preprint server for biology · 2024Article
- Activin A signaling stimulates neutrophil activation and macrophage migration in pancreatitis.Scientific reports · 2024Article
- Mitochondrial dysfunction in pancreatic acinar cells: mechanisms and therapeutic strategies in acute pancreatitis.Frontiers in immunology · 2024Review
- The role of CaCell calcium · 2023Review
- Membrane Contact Sites in Autophagy.Cells · 2022Review
- Network organisation and the dynamics of tubules in the endoplasmic reticulum.Scientific reports · 2021Article
- Intracellular CaInternational journal of molecular sciences · 2020Review
- Ion Channel Signature in Healthy Pancreas and Pancreatic Ductal Adenocarcinoma.Frontiers in pharmacology · 2020Review
- Changes in Calcium Homeostasis and Gene Expression Implicated in Epilepsy in Hippocampi of Mice OverexpressingInternational journal of molecular sciences · 2019Article
- Regulation of voltage-gated calcium channels by the ER calcium sensor STIM1.Current opinion in neurobiology · 2019Review
- The Orai CaThe Journal of physiology · 2019Article
- Mitochondrial junctions with cellular organelles: CaPflugers Archiv : European journal of physiology · 2018Review
- Can pancreatitis be treated by inhibiting CaAnnals of translational medicine · 2018Article
- SOCE induced calcium overload regulates autophagy in acute pancreatitis via calcineurin activation.Cell death & disease · 2018Article
- CaOncotarget · 2017Review
- CaNature communications · 2017Article
- ER-plasma membrane junctions: Why and how do we study them?Biochimica et biophysica acta. Molecular cell research · 2017Review
- CaThe Journal of physiology · 2017Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Store-operated Ca(2+) entry is a ubiquitous mechanism that prevents the depletion of endoplasmic reticulum (ER) calcium. A reduction of ER calcium triggers translocation of STIM proteins, which serve as calcium sensors in the ER, to subplasmalemmal puncta where they interact with and activate Orai channels. In pancreatic acinar cells, inositol 1,4,5-trisphosphate (IP(3)) receptors populate the apical part of the ER. Here, however, we observe that STIM1 translocates exclusively to the lateral and basal regions following ER Ca(2+) loss. This finding is paradoxical because the basal and lateral regions of the acinar cells contain rough ER (RER); the size of the ribosomes that decorate RER is larger than the distance that can be spanned by a STIM-Orai complex, and STIM1 function should therefore not be possible. We resolve this paradox and characterize ribosome-free terminals of the RER that form junctions between the reticulum and the plasma membrane in the basal and lateral regions of the acinar cells. Our findings indicate that different ER compartments specialize in different calcium-handling functions (Ca(2+) release and Ca(2+) reloading) and that any potential interference between Ca(2+) release and Ca(2+) influx is minimized by the spatial separation of the two processes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.