ReviewArchivos de bronconeumologia2010
[Role of toll-like receptors in respiratory diseases].
Review in Archivos de bronconeumologia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02028637 (Expression of Toll-Like Receptors 2 and 4 in Asthmatic Patients.), which is not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Expression of Toll-Like Receptors 2 and 4 in Asthmatic Patients.
Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Common virulence factors betweenCurrent research in microbial sciences · 2024Review
- Effects of Inhaled Corticosteroids on the Innate Immunological Response toInternational journal of molecular sciences · 2022Article
- Asthma with bronchial hypersecretion: expression of mucins and toll-like receptors in sputum and blood.Journal of asthma and allergy · 2017Article
- Article
- Expression of toll-like receptors 2 and 4 in subjects with asthma by total serum IgE level.Respiratory research · 2016Observational
- Linking Endotoxins, African Dust PM10 and Asthma in an Urban and Rural Environment of Puerto Rico.Mediators of inflammation · 2015Article
- Effect of different 1, 25-(OH)2D3 doses on high mobility group box1 and toll-like receptors 4 expression in lung tissue of asthmatic mice.International journal of clinical and experimental medicine · 2015Article
- Blueprints of signaling interactions between pattern recognition receptors: implications for the design of vaccine adjuvants.Clinical and vaccine immunology : CVI · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There has been growing interest in the last 10 years in the study of innate immunity, in particular because of the possible role that toll-like receptors (TLR) may play in the pathogenesis of some respiratory disease such as for example, asthma, chronic obstructive pulmonary disease, and infections. TLR are a family of type 1 transmembrane proteins, responsible for recognizing molecular patterns associated with pathogens (PAMP, pathogen-associated molecular patterns), and expressed by a broad spectrum of infectious agents. This recognition leads to quick production of cytokines and chemokines which provides a long-lasting adaptive response to the pathogen. Currently, it is considered that the administration of drugs which modulate the activity of these receptors upwards or downwards may represent major therapeutic progress for handling these diseases. The aim of this review is to describe the different TLS, define their possible role in the pathogenesis of the main respiratory diseases and finally, speculate over the therapeutic possibilities which their modulation, agonist or antagonist, offers as possible therapeutic targets.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.