Trial reportMetabolism: clinical and experimental2010
Acute altitude-induced hypoxia suppresses plasma glucose and leptin in healthy humans.
Trial report in Metabolism: clinical and experimental, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 70 citations in OpenAlex.
- Blood glucose concentration is unchanged during exposure to acute normobaric hypoxia in healthy humans.Physiological reports · 2021Trial
- Impact of exercise and moderate hypoxia on glycemic regulation and substrate oxidation pattern.PloS one · 2014Trial
- Effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation.PloS one · 2013Trial
- Obstructive sleep apnea is a predictor of abnormal glucose metabolism in chronically sleep deprived obese adults.PloS one · 2013Trial
- Effects and adaptation of high-altitude hypoxia on lipid metabolism: mechanisms and health implications.Frontiers in physiology · 2026Review
- Development and validation of an AI-driven blood glucose prediction system for pilots based on continuous glucose monitoring.Frontiers in physiology · 2026Article
- The impact of high altitude (hypobaric hypoxia) on insulin resistance in humans.Journal of physiology and biochemistry · 2025Review
- Variations in HBA gene contribute to high-altitude hypoxia adaptation via affected OFrontiers in zoology · 2024Article
- Effect of age on lung adaptation to high-altitude hypoxia in Tibetan sheep.Frontiers in veterinary science · 2024Article
- The role of exercise and hypoxia on glucose transport and regulation.European journal of applied physiology · 2023Review
- Mechanisms for Combined Hypoxic Conditioning and Divergent Exercise Modes to Regulate Inflammation, Body Composition, Appetite, and Blood Glucose Homeostasis in Overweight and Obese Adults: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2023Review
- The association between living altitude and serum leptin concentrations in native women.Frontiers in endocrinology · 2023Article
- Sprint Interval Exercise Improves Cognitive Performance Unrelated to Postprandial Glucose Fluctuations at Different Levels of Normobaric Hypoxia.Journal of clinical medicine · 2022Article
- Chronic Intermittent Hypoxia Exposure Alternative to Exercise Alleviates High-Fat-Diet-Induced Obesity and Fatty Liver.International journal of molecular sciences · 2022Article
- Variations inAnimals : an open access journal from MDPI · 2021Article
- Exercise intervention under hypoxic condition as a new therapeutic paradigm for type 2 diabetes mellitus: A narrative review.World journal of diabetes · 2021Review
- Inconvenience of Living Place Affects Individual HbA1c Level in a Rural Area in Japan: Shimane CoHRE Study.International journal of environmental research and public health · 2021Article
- Obesity, the most common comorbidity in SARS-CoV-2: is leptin the link?International journal of obesity (2005) · 2020Review
- Changes in expression of genes related to glucose metabolism in liver and skeletal muscle of rats exposed to acute hypoxia.Heliyon · 2020Article
- AMPK and the Need to Breathe and Feed: What's the Matter with Oxygen?International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
To examine the effects of acute altitude-induced hypoxia on the hormonal and metabolic response to ingested glucose, 8 young, healthy subjects (5 men and 3 women; age, 26 +/- 2 years; body mass index, 23.1 +/- 1.0 kg/m(2)) performed 2 randomized trials in a hypobaric chamber where a 75-g glucose solution was ingested under simulated altitude (ALT, 4300 m) or ambient (AMB, 362 m) conditions. Plasma glucose, insulin, C-peptide, epinephrine, leptin, and lactate concentrations were measured at baseline and 30, 60, 90, and 120 minutes after glucose ingestion during both trials. Compared with AMB, the plasma glucose response to glucose ingestion was reduced during the ALT trial (P = .04). There were no differences in the insulin and C-peptide responses between trials or in insulin sensitivity based on the homeostasis model assessment of insulin resistance. Epinephrine and lactate were both elevated during the ALT trial (P < .05), whereas the plasma leptin response was reduced compared with AMB (P < .05). The data suggest that the plasma glucose response is suppressed at ALT, but this is not due to insulin per se because insulin and C-peptide levels were similar for both trials. Elevated plasma epinephrine and lactate during ALT are indicative of increased glycogenolysis, which may have masked the magnitude of the reduced glucose response. We conclude that, during acute altitude exposure, there is a rapid metabolic response that is accompanied by a shift in the hormonal milieu that appears to favor increased glucose utilization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.