Evidence map›Paper›PMID 19765665›Full record

ReviewSeminars in cell & developmental biology2009

The stem cell--chromatin connection.

Yi Sang, Miin-Feng Wu, Doris Wagner

Abstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Epigenetics · 2023
    Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Butyrate histone deacetylase inhibitors.BioResearch open access · 2012
    Article
  9. Article
  10. RB1, development, and cancer.Current topics in developmental biology · 2011
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yi SangDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104, United States.
Miin-Feng Wu
Doris Wagner

Funding

The role of chromatin remodeling in developmentR01GM064650 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI WAGNER, DORIS · 2004 to 2008
$1.4M
NIGMS NIH HHS R01 GM064650
6 · The paper itself

Abstract

Stem cells self-renew and give rise to all differentiated cell types of the adult body. They are classified as toti-, pluri- or multi-potent based on the number of different cell types they can give rise to. Recently it has become apparent that chromatin regulation plays a critical role in determining the fate of stem cells and their descendants. In this review we will discuss the role of chromatin regulators in maintenance of stem cells and their ability to give rise to differentiating cells in both the animal and plant kingdom. We will highlight similarities and differences in chromatin-mediated control of stem cell fate in plants and animals. We will consider possible reasons why chromatin regulators play a central role in pluripotency in both kingdoms given that multicellularity evolved independently in each.

Indexed as

AnimalsCell DifferentiationCell LineageChromatinDNA MethylationGene Expression Regulation, DevelopmentalHistonesHumansModels, BiologicalPlantsStem CellsChromatinHistones

Identifiers

PMID19765665
PMCPMC3407560

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.