ReviewSeminars in cell & developmental biology2009
Scratching the niche that controls Caenorhabditis elegans germline stem cells.
Review in Seminars in cell & developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed.
- Linking tissue morphology and tissue healing in a cell-fate model.Frontiers in cell and developmental biology · 2026Article
- Three lncRNAs promote PUM protein condensation and germline differentiation.Nature communications · 2025Article
- Fexinidazole and Corallopyronin A target Wolbachia-infected sheath cells present in filarial nematodes.PLoS pathogens · 2025Article
- Fexinidazole and Corallopyronin A targetbioRxiv : the preprint server for biology · 2025Article
- Aging disrupts spatiotemporal regulation of germline stem cells and niche integrity.Biology open · 2024Article
- Somatic regulation of female germ cell regeneration and development in planarians.Cell reports · 2022Article
- Neuronal regulatedeLife · 2021Article
- Redox signaling as a modulator of germline stem cell behavior: Implications for regenerative medicine.Free radical biology & medicine · 2021Review
- Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells.Science (New York, N.Y.) · 2018Article
- The multipotency-to-commitment transition in Caenorhabditis elegans-implications for reprogramming from cells to organs.FEBS letters · 2018Review
- Identification of regulators of germ stem cell enwrapment by its niche in C. elegans.Developmental biology · 2017Article
- Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators.Cell stem cell · 2016Article
- Keeping stem cells under control: New insights into the mechanisms that limit niche-stem cell signaling within the reproductive system.Molecular reproduction and development · 2016Review
- Review
- Germline Stem Cell Differentiation Entails Regional Control of Cell Fate Regulator GLD-1 in Caenorhabditis elegans.Genetics · 2016Article
- A systematic mRNA control mechanism for germline stem cell homeostasis and cell fate specification.BMB reports · 2016Review
- Aiweixin, a traditional Uyghur medicinal formula, protects against chromium toxicity in Caenorhabditis elegans.BMC complementary and alternative medicine · 2015Article
- The Dynamic Duo: Niche/Stem Cell Interdependency.Stem cell reports · 2015Review
- Caenorhabditis elegans: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification.Biomolecules & therapeutics · 2014Review
- GLD-4-mediated translational activation regulates the size of the proliferative germ cell pool in the adult C. elegans germ line.PLoS genetics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The Caenorhabditis elegans gonad provides a well-defined model for a stem cell niche and its control of self-renewal and differentiation. The distal tip cell (DTC) forms a mesenchymal niche that controls germline stem cells (GSCs), both to generate the germline tissue during development and to maintain it during adulthood. The DTC uses GLP-1/Notch signaling to regulate GSCs; germ cells respond to Notch signaling with a network of RNA regulators to control the decision between self-renewal and entry into the meiotic cell cycle.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.