ArticleBrain, behavior, and immunity2010
Short-term stress enhances cellular immunity and increases early resistance to squamous cell carcinoma.
Article in Brain, behavior, and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.
- Chronic psychosocial stress: a role in breast cancer etiology?Frontiers in oncology · 2026Pooled it
- Aerobic Exercise Training and Inducible Inflammation: Results of a Randomized Controlled Trial in Healthy, Young Adults.Journal of the American Heart Association · 2018Trial
- Adverse effects of thermal pollution on rainbow trout (Oncorhynchus mykiss): unveiling the roles of heat shock proteins and acute-phase proteinsMette.Veterinary research communications · 2026Review
- Article
- Effect on the splenocyte function of weaned piglets induced by continuous lipopolysaccharide injections.Journal of veterinary research · 2024Article
- The Skin and Inflamm-Aging.Biology · 2023Review
- Working with Convex Responses: Antifragility from Finance to Oncology.Entropy (Basel, Switzerland) · 2023Article
- The Brain-Skin Axis in Psoriasis-Psychological, Psychiatric, Hormonal, and Dermatological Aspects.International journal of molecular sciences · 2022Review
- Stress and cancer: mechanisms, significance and future directions.Nature reviews. Cancer · 2021Review
- Adult skin acute stress responses to short-term environmental and internal aggression from exposome factors.Journal of the European Academy of Dermatology and Venereology : JEADV · 2021Review
- New Pathways for the Skin's Stress Response: The Cholinergic Neuropeptide SLURP-1 Can Activate Mast Cells and Alter Cytokine Production in Mice.Frontiers in immunology · 2021Article
- CCL27 Signaling in the Tumor Microenvironment.Advances in experimental medicine and biology · 2021Review
- Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma.Cancer prevention research (Philadelphia, Pa.) · 2020Article
- Measurable health effects associated with the daylight saving time shift.PLoS computational biology · 2020Article
- Chronic Stress Exposure Suppresses Mammary Tumor Growth and Reduces Circulating Exosome TGF-β Content via β-Adrenergic Receptor Signaling in MMTV-PyMT Mice.Breast cancer : basic and clinical research · 2020Article
- Effects of ultraviolet-B radiation on physiology, immune function and survival is dependent on temperature: implications for amphibian declines.Conservation physiology · 2020Article
- The impact of psychosocial stress and stress management on immune responses in patients with cancer.Cancer · 2019Review
- Less immune activation following social stress in rural vs. urban participants raised with regular or no animal contact, respectively.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The short-term stress response - Mother nature's mechanism for enhancing protection and performance under conditions of threat, challenge, and opportunity.Frontiers in neuroendocrinology · 2018Review
- Self-Regulation of Breathing as an Adjunctive Treatment of Insomnia.Frontiers in psychiatry · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
In contrast to chronic/long-term stress that suppresses/dysregulates immune function, an acute/short-term fight-or-flight stress response experienced during immune activation can enhance innate and adaptive immunity. Moderate ultraviolet-B (UV) exposure provides a non-invasive system for studying the naturalistic emergence, progression and regression of squamous cell carcinoma (SCC). Because SCC is an immunoresponsive cancer, we hypothesized that short-term stress experienced before UV exposure would enhance protective immunity and increase resistance to SCC. Control and short-term stress groups were treated identically except that the short-term stress group was restrained (2.5h) before each of nine UV-exposure sessions (minimum erythemal dose, 3-times/week) during weeks 4-6 of the 10-week UV exposure protocol. Tumors were measured weekly, and tissue collected at weeks 7, 20, and 32. Chemokine and cytokine gene expression was quantified by real-time PCR, and CD4+ and CD8+ T cells by flow cytometry and immunohistochemistry. Compared to controls, the short-term stress group showed greater cutaneous T-cell attracting chemokine (CTACK)/CCL27, RANTES, IL-12, and IFN-gamma gene expression at weeks 7, 20, and 32, higher skin infiltrating T cell numbers (weeks 7 and 20), lower tumor incidence (weeks 11-20) and fewer tumors (weeks 11-26). These results suggest that activation of short-term stress physiology increased chemokine expression and T cell trafficking and/or function during/following UV exposure, and enhanced Type 1 cytokine-driven cell-mediated immunity that is crucial for resistance to SCC. Therefore, the physiological fight-or-flight stress response and its adjuvant-like immuno-enhancing effects, may provide a novel and important mechanism for enhancing immune system mediated tumor-detection/elimination that merits further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.