Evidence map›Paper›PMID 19765321›Full record

Trial reportCritical care (London, England)2009

A randomized trial of chlorhexidine gluconate on oral bacterial pathogens in mechanically ventilated patients.

Frank A Scannapieco, Jihnhee Yu, Krishnan Raghavendran, Angela Vacanti, Susan I Owens, Kenneth Wood, Joseph M Mylotte

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Critical care (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00123123 (Oral Health and Ventilator-associated Pneumonia), which is not on this map. Cited by 53 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 8 pooled it
10.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00123123 phase2completednot on this map

Oral Health and Ventilator-associated Pneumonia

TypeinterventionalSponsorState University of New York at BuffaloRan2004 to 2007Enrolled175ConditionsPneumoniaArmschlorhexidine gluconate oral rinse (0.12%), placebo
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 8 syntheses or guidelines pooled it, 204 citations in OpenAlex.

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  9. Ventilator-associated pneumonia with or without toothbrushing: a randomized controlled trial.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012
    Trial
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Frank A ScannapiecoDepartment of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, 3435 Main St, Buffalo, NY 14214, USA. fas1@buffalo.edu
Jihnhee Yu
Krishnan Raghavendran
Angela Vacanti
Susan I Owens
Kenneth Wood
Joseph M Mylotte
University at Buffalo, State University of New York · USFrontier Science & Technology Research Foundation · US

Funding

Oral Health and Ventilator Associated PneumoniaR01DE014685 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI SCANNAPIECO, FRANK ANDREW · 2004 to 2006
$1.8M
NIDCR NIH HHS R01DE-14685
6 · The paper itself

Abstract

introductionDental plaque biofilms are colonized by respiratory pathogens in mechanically-ventilated intensive care unit patients. Thus, improvements in oral hygiene in these patients may prevent ventilator-associated pneumonia. The goal of this study was to determine the minimum frequency (once or twice a day) for 0.12% chlorhexidine gluconate application necessary to reduce oral colonization by pathogens in 175 intubated patients in a trauma intensive care unit.

methodsA randomized, double-blind, placebo-controlled clinical trial tested oral topical 0.12% chlorhexidine gluconate or placebo (vehicle alone), applied once or twice a day by staff nurses. Quantitation of colonization of the oral cavity by respiratory pathogens (teeth/denture/buccal mucosa) was measured.

resultsSubjects were recruited from 1 March, 2004 until 30 November, 2007. While 175 subjects were randomized, microbiologic baseline data was available for 146 subjects, with 115 subjects having full outcome assessment after at least 48 hours. Chlorhexidine reduced the number of Staphylococcus aureus, but not the total number of enterics, Pseudomonas or Acinetobacter in the dental plaque of test subjects. A non-significant reduction in pneumonia rate was noted in groups treated with chlorhexidine compared with the placebo group (OR = 0.54, 95% CI: 0.23 to 1.25, P = 0.15). No evidence for resistance to chlorhexidine was noted, and no adverse events were observed. No differences were noted in microbiologic or clinical outcomes between treatment arms.

conclusionsWhile decontamination of the oral cavity with chlorhexidine did not reduce the total number of potential respiratory pathogens, it did reduce the number of S. aureus in dental plaque of trauma intensive care patients.

Indexed as

MouthwashesRespiration, ArtificialAdolescentAdultAgedAged, 80 and overAnti-Infective Agents, LocalBacteriaChlorhexidineDouble-Blind MethodFemaleHumansMaleMiddle AgedMouthPlacebosAnti-Infective Agents, LocalChlorhexidinechlorhexidine gluconateMouthwashesPlacebos

Identifiers

PMID19765321
PMCPMC2750165
OpenAlexW2059441000

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.