ReviewJournal of internal medicine2009
Cellular origins of beta-cell regeneration: a legacy view of historical controversies.
Review in Journal of internal medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Article
- Advanced therapy to cure diabetes: mission impossible is now possible?Frontiers in cell and developmental biology · 2024Review
- Development, regeneration, and physiological expansion of functional β-cells: Cellular sources and regulators.Frontiers in cell and developmental biology · 2024Review
- Review
- Mechanisms controlling pancreatic islet cell function in insulin secretion.Nature reviews. Molecular cell biology · 2021Review
- Mitogen Synergy: An Emerging Route to Boosting Human Beta Cell Proliferation.Frontiers in cell and developmental biology · 2021Review
- A Method for Identifying Mouse Pancreatic Ducts.Tissue engineering. Part C, Methods · 2018Article
- β Cells Persist in T1D Pancreata Without Evidence of Ongoing β-Cell Turnover or Neogenesis.The Journal of clinical endocrinology and metabolism · 2017Article
- Cdk5r1 Overexpression Induces Primary β-Cell Proliferation.Journal of diabetes research · 2016Article
- High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice.American journal of physiology. Endocrinology and metabolism · 2015Article
- Article
- Article
- Pathogenesis of pancreatic cancer: lessons from animal models.Toxicologic pathology · 2014Review
- Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression.American journal of physiology. Endocrinology and metabolism · 2013Article
- Anonymous sources: where do adult β cells come from?The Journal of clinical investigation · 2013Article
- Stem cell therapy to cure type 1 diabetes: from hype to hope.Stem cells translational medicine · 2013Review
- Article
- The role of aging upon β cell turnover.The Journal of clinical investigation · 2013Review
- Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration.Development (Cambridge, England) · 2013Article
- Histopathological changes in the pancreas from a spontaneous hyperglycemic cynomolgus monkey.Journal of toxicologic pathology · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Beta-cell regeneration represents a major goal of therapy for diabetes. Unravelling the origin of beta cells during pancreatic regeneration could help restore a functional beta-cell mass in diabetes patients. This scientific question has represented a longstanding interest still intensively investigated today. This review focuses on pioneering observations and subsequent theories made 100 years ago and describes how technical innovation helped resolve some, but not all, of the controversies generated by these early investigators. At the end of the 19th century, complete pancreatectomy demonstrated the crucial physiological role of the pancreas and its link with diabetes. Pancreatic injury models, including pancreatectomy and ductal ligation, allowed investigators to describe islet function and to assess the regenerative capacity of the pancreas. Three main theories were proposed to explain the origins of newly formed islets: (i) transdifferentiation of acinar cells into islets, (ii) islet neogenesis, a process reminiscent of islet formation during embryonic development, and (iii) replication of preexisting islet cells. Despite considerable technical innovation in the last 50 years, the origin of new adult beta cells remains highly controversial and the same three theories are still debated today.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.