ArticleInternational journal of experimental pathology2009
Matrix metalloproteinases with gelatinolytic activity induced by Paracoccidioides brasiliensis infection.
Article in International journal of experimental pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
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- Combined Silymarin and Cotrimoxazole Therapy Attenuates Pulmonary Fibrosis in Experimental Paracoccidioidomycosis.Journal of fungi (Basel, Switzerland) · 2022Article
- Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosis.Scientific reports · 2018Article
- Dermatophytes activate skin keratinocytes via mitogen-activated protein kinase signaling and induce immune responses.Infection and immunity · 2015Article
- Article
- Dramatic early event in chronic allograft nephropathy: increased but not decreased expression of MMP-9 gene.Diagnostic pathology · 2013Article
- TNF-α and CD8+ T cells mediate the beneficial effects of nitric oxide synthase-2 deficiency in pulmonary paracoccidioidomycosis.PLoS neglected tropical diseases · 2013Article
- Lung dendritic cells facilitate extrapulmonary bacterial dissemination during pneumococcal pneumonia.Frontiers in cellular and infection microbiology · 2013Article
- Diverse microbial interactions with the basement membrane barrier.Trends in microbiology · 2012Review
- MMP-9 activity is induced by Leishmania braziliensis infection and correlates with mucosal leishmaniasis.Acta tropica · 2011Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Matrix metalloproteinases (MMPs) modulate extracellular matrix turnover, inflammation and immunity. We studied MMP-9 and MMP-2 in experimental paracoccidioidomycosis. At 15 and 120 days after infection (DAI) with virulent Paracoccidioides brasiliensis, MMP-9 was positive by immunohistochemistry in multinucleated giant cells, in mononuclear cells with macrophage and lymphocyte morphologies and also in fungal cells in the lesions of susceptible and resistant mice. Using gelatin zymography, pro- and active MMP-9 and active MMP-2 were detected in all infected mice, but not in controls. Gelatinolytic activity was not observed in P. brasiliensis extracts. Semiquantitative analysis of gelatinolytic activities revealed weak or absent MMP-2 and strong MMP-9 activity in both mouse strains at 15 DAI, declining at 120 DAI. Avirulent P. brasiliensis-infected mice had residual lesions with MMP-9-positive pseudoxantomatous macrophages, but no gelatinase activity at 120 DAI. Our findings demonstrate the induction of MMPs, particularly MMP-9, in experimental paracoccidioidomycosis, suggesting a possible influence in the pattern of granulomas and in fungal dissemination.
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