ArticleThe EMBO journal1990
Expression of a homeobox gene in the chick wing bud following application of retinoic acid and grafts of polarizing region tissue.
Article in The EMBO journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 108 citations in OpenAlex.
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- A new clade of basal Early Cretaceous pygostylian birds and developmental plasticity of the avian shoulder girdle.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Application of synthetic photostable retinoids induces novel limb and facial phenotypes during chick embryogenesis in vivo.Journal of anatomy · 2014Article
- miR-196 regulates axial patterning and pectoral appendage initiation.Developmental biology · 2011Article
- Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Review
- Scapula development is governed by genetic interactions of Pbx1 with its family members and with Emx2 via their cooperative control of Alx1.Development (Cambridge, England) · 2010Article
- Homology of the reptilian coracoid and a reappraisal of the evolution and development of the amniote pectoral apparatus.Journal of anatomy · 2006Review
- An autoregulatory element of the murine Hox-4.2 gene.The EMBO journal · 1992Article
- Expression of Hox-4 genes in the chick wing links pattern formation to the epithelial-mesenchymal interactions that mediate growth.The EMBO journal · 1992Article
- Hypertrophic chondrocytes undergo further differentiation in culture.The Journal of cell biology · 1992Article
- The upstream region of the human homeobox gene HOX3D is a target for regulation by retinoic acid and HOX homeoproteins.The EMBO journal · 1992Article
- The expression of murine Hox-2 genes is dependent on the differentiation pathway and displays a collinear sensitivity to retinoic acid in F9 cells and Xenopus embryos.Nucleic acids research · 1991Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Homeobox gene XlHbox 1 is expressed in a mesodermal gradient in vertebrate forelimbs with maximal expression anteriorly and proximally and may encode positional values. In chick wing buds, anterior cells can be reprogrammed to form posterior structures by grafts of polarizing region tissue and by beads soaked in retinoic acid (RA), which is a good candidate for an endogenous morphogen. Applications of RA anteriorly or at the bud apex, treatments which produce duplicated digits or truncations respectively, substantially increase the extent of mesodermal XlHbox 1 expression. Polarizing region grafts that also produce additional digits lead to a moderate increase. The effects of RA application and the behaviour of transplanted tissue show that only anterior cells are competent to express XlHbox 1 and that expression is cell autonomous. Ectodermal expression in wing buds is enhanced by RA but not by polarizing region grafts and ectoderm/mesoderm recombinations show that the mesoderm is irreversibly affected. The changes in mesodermal expression do not fit the predictions of the simple model that XlHbox 1 encodes anterior positional values but are correlated with a series of novel malformations of the shoulder girdle which, in normal wing buds, is derived from cells expressing XlHbox 1.
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