ReviewClinical and experimental immunology2009
Minimal persistent inflammation in allergic rhinitis: implications for current treatment strategies.
Review in Clinical and experimental immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 123 citations in OpenAlex.
- Could FeNO Predict Asthma in Patients with House Dust Mites Allergic Rhinitis?Medicina (Kaunas, Lithuania) · 2020Trial
- Persistent Off-Season Dysregulation of Memory B Cell Subsets in Allergic Rhinitis.Clinical and translational allergy · 2025Article
- Characterizing the symptomatology and pathophysiology of allergic rhinitis using a nasal allergen challenge model - a subset of the allergic rhinitis microbiome study.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2025Article
- A randomized controlled trial evaluating prophylactic treatment ofFrontiers in allergy · 2025Article
- Molecular characteristics of atopic dermatitis patients with clinical remission.The World Allergy Organization journal · 2024Article
- Twenty-five years: The fexofenadine clinical experience.The World Allergy Organization journal · 2024Review
- The effectiveness and safety of acupoint herbal patching for allergic rhinitis: protocol for a systematic review and meta-analysis.Systematic reviews · 2024Article
- General practitioner and patient perspectives on intranasal corticosteroids for allergic rhinitis: Treatment duration and obstacles to adherence, findings from a recent survey.The World Allergy Organization journal · 2024Article
- Dendritiform immune cells with reduced antigen-capture capacity persist in the cornea during the asymptomatic phase of allergic conjunctivitis.Eye (London, England) · 2023Article
- Factors affecting adherence to intranasal treatment for allergic rhinitis: A qualitative study.Laryngoscope investigative otolaryngology · 2023Article
- Using eye drops in compliance may improve the symptoms and quality of life in patients with seasonal allergic conjunctivitis: analysis of a two-season web survey.International journal of ophthalmology · 2023Article
- Clinical Characteristics of Patients with Dental Malocclusion: An Otolaryngologic Perspective.Journal of clinical medicine · 2022Article
- Impact of the COVID-19 national lockdown in the allergic rhinitis symptoms in patients treated with immunotherapy at two allergy referral centers in Bogotá, Colombia.Laryngoscope investigative otolaryngology · 2022Article
- Are Markers of Allergic Inflammation in Grass Pollen Allergy Influenced by H1 Antihistamines?Journal of clinical medicine · 2021Article
- Effectiveness of mobile health interventions to improve nasal corticosteroid adherence in allergic rhinitis: A systematic review.Clinical and translational allergy · 2021Review
- The Influence of Air Pollution on the Development of Allergic Inflammation in the Airways in Krakow's Atopic and Non-Atopic Residents.Journal of clinical medicine · 2021Article
- The performance of the alarmin HMGB1 in pediatric diseases: From lab to clinic.Immunity, inflammation and disease · 2021Review
- [The observation and evaluation of curative effect of nasal mucosa dryness, hemorrhae and erosion].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021Article
- COVID-19: When dust mites and lockdown create the perfect storm.Laryngoscope investigative otolaryngology · 2020Article
- IL-37 relieves allergic inflammation by inhibiting the CCL11 signaling pathway in a mouse model of allergic rhinitis.Experimental and therapeutic medicine · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with allergic rhinitis have traditionally been placed into 'seasonal' and 'perennial' categories, which do not account for the subclinical inflammatory state that exists in many patients. In subjects with seasonal and perennial allergic rhinitis, even subthreshold doses of allergen have been found to cause inflammatory cell infiltration in the nasal mucosa, including increases in expression of cellular adhesion molecules, nasal and conjunctival eosinophilia, and other markers of inflammation, which do not result in overt allergy symptoms. This state - which has been termed 'minimal persistent inflammation'- may contribute to hyperreactivity and increased susceptibility to development of clinical symptoms as well as common co-morbidities of allergic rhinitis, such as asthma. Treating overt allergy symptoms as well as this underlying inflammatory state requires agents that have well-established clinical efficacy, convenient administration, potent anti-inflammatory effects and proven long-term safety, so that long-term continuous administration is feasible. Of the three major classes of commonly used allergic rhinitis medications - intranasal corticosteroids, anti-histamines, and anti-leukotrienes - intranasal corticosteroids appear to represent the most reasonable therapeutic option in patients who would benefit from continuous inhibition of persistent inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.