Trial reportChild development
Three randomized controlled trials of early long-chain polyunsaturated Fatty Acid supplementation on means-end problem solving in 9-month-olds.
Trial report in Child development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Supplementation of Infant Formula and Neurodevelopmental Outcomes: a Systematic Review.Current nutrition reports · 2022Pooled it
- Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy.The Cochrane database of systematic reviews · 2016Pooled it
- Low linoleic acid foods with added DHA given to Malawian children with severe acute malnutrition improve cognition: a randomized, triple-blinded, controlled clinical trial.The American journal of clinical nutrition · 2022Trial
- Long-term effects of LCPUFA supplementation on childhood cognitive outcomes.The American journal of clinical nutrition · 2013Trial
- Human Milk as a Model for Next-Generation Infant Formula: Opportunities and Challenges.Advances in nutrition (Bethesda, Md.) · 2026Review
- Breastfeeding and Children's Cognitive Development up to the Age of 4 Years: The Japan Environment and Children's Study.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2024Article
- Impacts of Omega-3 Fatty Acids, Natural Elixirs for Neuronal Health, on Brain Development and Functions.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Asinine milk mitigates stress-mediated immune, cortisol and behavioral responses of piglets to weaning: A study to foster future interventions in humans.Frontiers in immunology · 2023Article
- Health benefits of docosahexaenoic acid and its bioavailability: A review.Food science & nutrition · 2021Review
- Can Eating Make Us More Creative? A Multisensory Perspective.Foods (Basel, Switzerland) · 2021Review
- The development of a cognitive rehabilitation task for mice.Neurobiology of learning and memory · 2020Article
- Sacha inchi (Plukenetia volubilis L.)-from lost crop of the Incas to part of the solution to global challenges?Planta · 2020Review
- Psychological effects of breastfeeding on children and mothers.Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2018Review
- Influence of High-Fat Diets Consumed During the Juvenile Period on Hippocampal Morphology and Function.Frontiers in cellular neuroscience · 2018Review
- Prenatal fish oil supplementation and early childhood development in the Upstate KIDS Study.Journal of developmental origins of health and disease · 2017Observational
- Article
- Food for thought: how nutrition impacts cognition and emotion.NPJ science of food · 2017Review
- DHA Effects in Brain Development and Function.Nutrients · 2016Review
- Breastfeeding and trajectories of children's cognitive development.Developmental science · 2014Article
- Essential fats: how do they affect growth and development of infants and young children in developing countries? A literature review.Maternal & child nutrition · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
This study examines whether feeding infants formula supplemented with long-chain polyunsaturated fatty acids (LCPUFA) improves cognitive function of 9-month-olds. Participants included 229 infants from 3 randomized controlled trials. Children received either formula supplemented with docosahexaenoic acid and arachidonic acid, or a control formula beginning at 1-5 days (12-month feeding study), or following 6 weeks (6-week-weaning study) or 4-6 months of breastfeeding (4-to 6-month weaning study). Infants were assessed with a 2-step problem solving task. In the 12-month feeding and 6-week weaning studies, supplemented children had more intentional solutions (successful task completions) and higher intention scores (goal-directed behaviors) than controls. These results suggest that LCPUFA supplementation improves means-end problem solving.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.